Ion channels in interstitial cells of Cajal as targets for neurotransmitter action
Ion channels in interstitial cells of Cajal as targets for neurotransmitter action
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DOI：
10.1111/j.1743-3150.2004.00484.x
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发表时间：
2004-04-01
影响因子：
3.5
通讯作者：
White, EJ
中科院分区：
文献类型：
--
作者：
Huizinga, JD;Golden, CM;White, EJ
Cajal间质细胞（ICC）参与肠道起搏器活动、神经传递和伸展感觉的产生。起搏器ICC表现出与起搏器活动同步的自发循环钙振荡。肠起搏器活动背后的ICC自发节律性内向电流与这种钙振荡有关。可能不止一种类型的通道有助于向内电流，其中高电导氯离子通道和非选择性阳离子通道是主要的候选者。这些通道的激活与细胞内钙循环机制有关，并涉及肌醇1,4,5-三磷酸（IP3）介导的钙从肌浆网释放和钙摄取到线粒体。这种离子通道的活性通过神经递质受体（包括NK1受体）的信号传导来调节。这一发现和其他神经递质受体mRNA转录物的存在表明，ICC中的离子通道是神经递质作用的靶点。乙醚相关（ERG） K通道可能是影响ICC静息膜电位和兴奋性的最重要的K通道。ICC中的许多离子通道是由第二信使系统调节的，这使得它们对神经递质调节非常敏感。
Interstitial cells of Cajal (ICC) are involved in generation of gut pacemaker activity, neurotransmission and stretch sensation. Pacemaker ICC exhibit spontaneous cyclic calcium oscillations that are in synchrony with its pacemaker activity. The spontaneous rhythmic inward currents in ICC that underlie gut pacemaker activity are linked to this calcium oscillation. It is probable that more than one type of channel contributes to the inward current with a high conductance chloride channel and a nonselective cation channel being the main candidates. The activation of these channels is linked to intracellular calcium cycling mechanism and involves inositol 1,4,5-trisphosphate (IP3)-mediated calcium release from the sarcoplasmic reticulum, and calcium uptake into mitochondria. This ion channel activity is modulated by signalling through neurotransmitter receptors, including the NK1 receptor. This finding and the presence of other neurotransmitter receptor mRNA transcripts indicates that ion channels in ICC are targets for neurotransmitter action. The ether-a-go-go-related (ERG) K channel is probably the most important K channel contributing to the resting membrane potential and excitability of the ICC. Many ion channels in ICC are regulated by second messenger systems which makes them highly susceptible to neurotransmitter modulation.