Encapsulated, genetically modified cells producing in vivo therapeutics.
Encapsulated, genetically modified cells producing in vivo therapeutics.
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封装的转基因细胞产生体内疗法。
DOI：
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发表时间：
2004
影响因子：
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通讯作者：
Brian Salmons
中科院分区：
文献类型：
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作者：
O. Hauser;E. Prieschl;Brian Salmons
将转基因细胞植入免疫隔离材料的能力具有很大的治疗用途潜力。这篇综述介绍了可用于封装细胞的不同类型的聚合物，以及最近使用转基因、封装和免疫保护的细胞来治疗动物模型和临床试验中的疾病。还讨论了这些技术面临的一些挑战和潜在的解决方案。
The ability to implant genetically modified cells in immuno-isolating materials has much potential for therapeutic use. This review presents the different types of polymer that can be used for encapsulation of cells and the recent use of genetically modified, encapsulated and thus immunoprotected cells for the treatment of diseases in animal models and clinical trials. Some of the challenges faced by these technologies and potential solutions are also discussed.