2D‐Black‐Phosphorus‐Reinforced 3D‐Printed Scaffolds:A Stepwise Countermeasure for Osteosarcoma
2D‐Black‐Phosphorus‐Reinforced 3D‐Printed Scaffolds:A Stepwise Countermeasure for Osteosarcoma
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DOI：
10.1002/adma.201705611
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发表时间：
2018-03
影响因子：
29.4
通讯作者：
Bowen Yang;J. Yin;Yu Chen;Shanshan Pan;Heliang Yao;Youshui Gao;Jianlin Shi
中科院分区：
文献类型：
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作者：
Bowen Yang;J. Yin;Yu Chen;Shanshan Pan;Heliang Yao;Youshui Gao;Jianlin Shi
随着对纳米生物相互作用的深入理解和纳米材料制造方法的发展，已经开发出各种基于纳米材料的治疗平台用于下一代肿瘤学应用，例如骨肉瘤治疗。在这项工作中，设计并制备了一种黑磷（BP）增强的3D打印支架，为骨肉瘤的有效局部治疗提供了可行的对策。支架内BP纳米片的原位磷驱动、钙提取的生物矿化使得骨肉瘤的光热消融和随后的生理微环境中的材料引导的骨再生成为可能，同时赋予支架独特的物理化学性质，有利于整个分步治疗过程。此外，在新生SD大鼠颅骨组织中发现了类似于哈佛管的波纹状结构，这可能为骨组织工程的未来研究提供了很多启示。
With the ever‐deeper understanding of nano–bio interactions and the development of fabrication methodologies of nanomaterials, various therapeutic platforms based on nanomaterials have been developed for next‐generation oncological applications, such as osteosarcoma therapy. In this work, a black phosphorus (BP) reinforced 3D‐printed scaffold is designed and prepared to provide a feasible countermeasure for the efficient localized treatment of osteosarcoma. The in situ phosphorus‐driven, calcium‐extracted biomineralization of the intra‐scaffold BP nanosheets enables both photothermal ablation of osteosarcoma and the subsequent material‐guided bone regeneration in physiological microenvironment, and in the meantime endows the scaffolds with unique physicochemical properties favoring the whole stepwise therapeutic process. Additionally, a corrugated structure analogous to Haversian canals is found on newborn cranial bone tissue of Sprague–Dawley rats, which may provide much inspiration for the future research of bone‐tissue engineering.