Perspective of strategic plasma therapy in patients with epithelial ovarian cancer: A short review of plasma in cancer treatment
Perspective of strategic plasma therapy in patients with epithelial ovarian cancer: A short review of plasma in cancer treatment
复制标题
DOI：
10.7567/jjap.53.05fa05
复制
发表时间：
2014-05-01
影响因子：
1.5
通讯作者：
Kikkawa, Fumitaka
中科院分区：
文献类型：
--
作者：
Kajiyama, Hiroaki;Nakamura, Kae;Kikkawa, Fumitaka
上皮性卵巢癌（EOC）是西方国家女性癌症相关死亡的主要原因。一旦患者复发，完全治愈几乎是不可能的。非平衡大气压等离子体疗法是近年来备受关注的一种新型医疗实践。我们阐明了非平衡大气压等离子体对EOC生长的影响，特别是在等离子体活化介质（PAM）中。在我们最近的报告中，我们研究了活性氧（ROS）或其清除剂在慢性抗肿瘤药耐药EOC细胞中的作用。结果表明，PAM在体外和体内均能发挥EOC细胞的抗肿瘤作用，即使在化疗耐药细胞中也能发挥作用。PAM抗肿瘤作用的细胞内机制和体内不良反应仍是研究的热点。通过最近关于血浆在癌症治疗中的结果，PAM治疗是EOC的一种有希望的治疗选择，并可能有助于改善未来的患者预后。(C)2014日本应用物理学会
Epithelial ovarian cancer (EOC) is the leading cause of cancer-related death in women in Western countries. Once patients experience recurrence, complete cure is almost impossible. Nonequilibrium atmospheric pressure plasma (NEAPP) therapy has recently been focused on as a novel medical practice. We have elucidated the effect of nonequilibrium atmospheric pressure plasma on the growth of EOC, particularly in plasma-activated medium (PAM). In our recent report, we examined the role of reactive oxygen species (ROS) or their scavengers in chronic antineoplastic-resistant EOC cells. As a result, PAM exerted the antitumor effect of EOC cells in vitro and in vivo, even in chemoresistant cells. There are several problems under investigation, including intracellular mechanism of antitumor effect by PAM and adverse event in vivo. Through recent results about plasma in cancer treatment, PAM therapy is a promising treatment option for EOC and may contribute to a better patient prognosis in the future. (C) 2014 The Japan Society of Applied Physics