Association between paternally inherited Haplotypes upstream of the insulin gene and umbilical cord IGF-II levels
Association between paternally inherited Haplotypes upstream of the insulin gene and umbilical cord IGF-II levels
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DOI：
10.1203/pdr.0b013e3181425841
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发表时间：
2007-10-01
影响因子：
3.6
通讯作者：
Morrison, John C.
中科院分区：
文献类型：
--
作者：
Adkins, Ronald M.;Fain, John N.;Morrison, John C.
胰岛素（INS）和IGF2 （IGF2）基因彼此接近，并在胎儿生长过程中经历母体印记。我们研究了207对健康的非洲裔美国母亲-新生儿的母体和脐带IGF- 2蛋白（IGF- ii）水平与INS和IGF2基因单核苷酸多态性（snp）之间的关系。未发现母体IGF-II水平与INS-IGF2位点多态性之间存在关联。新生儿IGF-II水平与INS-IGF2位点5'端的两个snp （rs3842738和rs689）之间存在显著关联。从这两个snp推断的单倍型分析表明，父亲遗传的单倍型与新生儿IGF-II水平之间存在显著关系，但与母亲遗传的单倍型无关。
The insulin (INS) and IGF 2 (IGF2) genes are in close proximity to each other and undergo maternal imprinting during fetal growth. We investigated the association between maternal and umbilical cord IGF 2 protein (IGF-II) levels and single nucleotide polymorphisms (SNPs) in the INS and IGF2 genes in 207 healthy African-American mother-newborn pairs. No association was found between maternal IGF-II levels and polymorphism in the INS-IGF2 locus. A significant association was found between newborn IGF-II levels and two SNPs (rs3842738 and rs689) at the 5' end of the INS-IGF2 focus. Analyses of haplotypes inferred from these two SNPs demonstrate a significant relationship between paternally transmitted haplotypes and newborn IGF-II levels, but no association with maternally transmitted haplotypes.