Exploring conditional gene essentiality through systems genetics approaches in yeast
Exploring conditional gene essentiality through systems genetics approaches in yeast
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DOI：
10.1016/j.gde.2022.101963
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发表时间：
2022-10-01
影响因子：
4
通讯作者：
van Leeuwen, Jolanda
中科院分区：
文献类型：
--
作者：
Bosch-Guiteras, Nuria;van Leeuwen, Jolanda
必需基因编码生存所需的细胞功能。虽然在酵母中生存力是一个简单的分析表型，但将基因定义为必需基因并不总是微不足道的。基因必要性通常在特定的实验室菌株和标准生长条件下进行研究，然而，必要性可能因物种、菌株和环境而异。最近对基因重要性的系统研究表明，存在两组必需基因：核心必需基因和条件必需基因，核心必需基因总是维持生存所必需的，条件必需基因在不同的遗传和环境背景下的重要性不同。在这里，我们回顾了最近的进展，在酵母基因的必要性的系统分析和讨论的属性，区分核心上下文依赖的必需基因。
An essential gene encodes for a cellular function that is required for viability. Although viability is a straightforward phenotype to analyze in yeast, defining a gene as essential is not always trivial. Gene essentiality has generally been studied in specific laboratory strains and under standard growth conditions, however, essentiality can vary across species, strains, and environments. Recent systematic studies of gene essentiality revealed that two sets of essential genes exist: core essential genes that are always required for viability and conditional essential genes that vary in essentiality in different genetic and environmental contexts. Here, we review recent advances made in the systematic analysis of gene essentiality in yeast and discuss the properties that distinguish core from context-dependent essential genes.