Activation and resolution of periodontal inflammation and its systemic impact.
Activation and resolution of periodontal inflammation and its systemic impact.
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DOI：
10.1111/prd.12105
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发表时间：
2015-10
影响因子：
18.6
通讯作者：
Kantarci A
中科院分区：
文献类型：
--
作者：
Hasturk H;Kantarci A
炎症是影响器官、组织和生物系统的高度有组织的事件。牙周病的特征在于炎症消退途径的失调或功能障碍，导致愈合失败和主要的慢性、进行性、破坏性和主要未消退的炎症。炎症过程的生物学后果可能与病原体如创伤、微生物和应激无关。炎症病理过程的影响取决于受影响的组织或器官系统。虽然介质相似，但炎症事件具有组织特异性。一个器官的炎症过程可能直接导致另一个器官或组织的病理学，这是合理的。身体的远距离部分和它们的炎症状态之间的通信也由经由细胞和可溶性介质介导的常见信号传导机制介导。本文综述了牙周炎症及其系统性相关性，以及基于介体通过协调天然途径解决炎症的治疗方法的进展。我们还讨论了一种新的治疗概念，其中牙周炎症的自然解决途径可用于限制全身炎症，促进愈合和再生。
Inflammation is a highly organized event impacting upon organs, tissues and biological systems. Periodontal diseases are characterized by dysregulation or dysfunction of resolution pathways of inflammation resulting in a failure of healing and a dominant chronic, progressive, destructive and predominantly unresolved inflammation. The biological consequences of inflammatory processes may be independent of the etiological agents such as trauma, microbial organisms and stress. The impact of the inflammatory pathological process depends upon the affected tissues or organ system. Whilst mediators are similar, there is a tissue specificity for the inflammatory events. It is plausible that inflammatory processes in one organ could directly lead to pathologies in another organ or tissue. Communication between distant parts of the body and their inflammatory status is also mediated by common signaling mechanisms mediated via cells and soluble mediators. This review focuses on periodontal inflammation, its systemic associations and advances in therapeutic approaches based on mediators acting through orchestration of natural pathway to resolution of inflammation. We also discuss a new treatment concept where natural pathways of resolution of periodontal inflammation can be used to limit systemic inflammation and promote healing and regeneration.