Tissue specificity: the clinical importance of steroid metabolites in hormone replacement therapy
Tissue specificity: the clinical importance of steroid metabolites in hormone replacement therapy
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DOI：
10.1016/s0378-5122(00)00169-9
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发表时间：
2001-01-31
期刊：
影响因子：
4.9
通讯作者：
Huber, JC
中科院分区：
文献类型：
--
作者：
Gruber, DM;Huber, JC
雌激素、孕激素和雄激素的代谢激活或失活是理解这些激素在雌性生物体中的生理和病理作用的重要步骤。性类固醇的组织特异性代谢途径的分析将导致更好地了解成功的激素替代治疗，一方面和类固醇激素相关的副作用的发生，另一方面。在这篇文章中，我们分析了组织特异性代谢物合成的不同机制，并讨论了这些代谢物在激素替代治疗中的治疗重要性。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Metabolic activations or inactivations of estrogens, progesterone and androgens are important steps towards the understanding of the physiological and the pathological effects of these hormones in the female organism. Analysis of the tissue specific metabolic pathways of sex steroids will result in a better understanding of successful hormone replacement therapy on the one hand and of the occurrence of steroid hormone related side effects on the other hand. In this contribution we analyse the different mechanisms involved in the synthesis of tissue specific metabolites and discuss the therapeutical importance of these metabolites in hormone replacement therapy. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.