Vaccination against hydatidosis using a defined recombinant antigen
Vaccination against hydatidosis using a defined recombinant antigen
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DOI：
10.1111/j.1365-3024.1996.tb01029.x
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发表时间：
1996-09-01
影响因子：
2.2
通讯作者：
Heath, DD
中科院分区：
文献类型：
--
作者：
Lightowlers, MW;Lawrence, SB;Heath, DD
细粒棘球绦虫是人和动物包虫病的病原体。寄生虫的自然传播发生在作为最终宿主和动物中间宿主的狗之间。迫切需要改进控制寄生虫传播的方法。在这里，我们描述了一种疫苗的基础上，从寄生虫卵（六钩蚴）克隆重组抗原的发展。用命名为EG95的抗原接种的绵羊对由E.颗粒虫卵该疫苗将提供一种有价值的新工具，以帮助控制这种重要的人类病原体的传播。它也有可能直接通过人类接种疫苗来预防包虫病。
Echinococcus granulosus is the causative agent of hydatid disease in humans and animals. Natural transmission of the parasite occurs between dogs as definitive hosts and animal intermediate hosts. There is an la gent need for improved methods to control the parasite's transmission. Here we describe the development of a vaccine based on a cloned recombinant antigen from the parasite egg (oncosphere). Sheep vaccinated with the antigen, designated EG95, are protected (mean 96-98%) against hydatidosis developing from an experimental challenge infection with E. granulosus eggs. The vaccine will provide a valuable new tool to aid in control of transmission of this important human pathogen. It also has the potential to prevent hydatid disease directly through vaccination of humans.