The diagnosis and treatment of gastrinoma and Zollinger-Ellison syndrome
The diagnosis and treatment of gastrinoma and Zollinger-Ellison syndrome
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胃泌素瘤和佐林格-埃利森综合征的诊断和治疗
DOI：
10.1007/978-1-4613-2849-0_13
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
D. McCarthy
中科院分区：
文献类型：
--
作者：
D. McCarthy
二十八年前，罗伯特·佐林格和埃德温·埃里森描述了现在以他们的名字命名的综合症[1]。佐林格-埃里森综合征 (ZES) 包括通常的胃外科手术无法缓解的暴发性消化性溃疡病，伴有严重的胃酸分泌过多，并与胰腺中存在非特异性胰岛细胞肿瘤有关。虽然他们不是第一个注意到溃疡和胰腺内分泌肿瘤之间关联的人，但他们是第一个记录胃酸大量分泌过多的人，胃酸分泌过多与病症有关，并且仍然是诊断的基本要求。他们认为肿瘤释放的激素导致胃分泌酸。这一启发性的猜测在五年内从肿瘤中提取了一种在生物测定中具有活性的“类胃泌素”物质[2]，随后证明该材料的化学结构与胃泌素相同[3]。这导致该肿瘤被命名为“胃泌素瘤”，并导致人们短暂地认为孤立性胃泌素瘤（通常是良性的）是该综合征的主要原因。在首次描述后的两年内，ZES 与 I 型多发性内分泌肿瘤 (MEN-I) 的关联性得到了认可 [4]，但这种关联的确切性质仍不清楚。
Twenty-eight years ago, Robert Zollinger and Edwin Ellison described the syndrome which now bears their names [1]. The Zollinger-Ellison syndrome (ZES) consisted of fulminant peptic ulcer disease not relieved by the usual gastric surgical procedures, accompanied by severe hypersecretion of gastric acid and associated with the presence of nonspecific islet cell tumors in the pancreas. While not the first to note the association between ulcers and pancreatic endocrine tumors, they were the first to document the massive hypersecretion of gastric acid which linked the conditions and which remains the essential requirement for diagnosis. They suggested that a hormone released by the tumor caused the stomach to secrete acid. This inspired guess was followed within five years by extraction from the tumor of a ‘gastrin-like’ substance active on bioassay [2], and later by demonstration that the material was identical to gastrin in its chemical structure [3]. This led to the tumor being designated ‘gastrinoma,’ and to the short-lived belief that solitary gastrinomas, often benign, were the main cause of the syndrome. Within two years of its first description, the association of ZES with multiple endocrine neoplasia — type I (MEN-I) was recognized [4], though much remains unclear as to the precise nature of the association.
肾上腺素能调节人体膨胀引起的胃泌素释放。
影响因子：
29.4
作者：
Peters,MN;Walsh,JH;Ferrari,J;Feldman,M
通讯作者：
Feldman,M
高胃泌素血症、高胃蛋白酶原血症 I 型十二指肠溃疡的家庭研究。
影响因子：
39.2
作者：
Taylor,IL;Calam,J;Rotter,JI;Vaillant,C;Samloff,IM;Cook,A;Simkin,E;Dockray,GJ
通讯作者：
Dockray,GJ
手术在佐林格-埃里森综合征中的作用。
影响因子：
9
作者：
Thompson,JC;Lewis,BG;Wiener,I;TownsendJr,CM
通讯作者：
TownsendJr,CM