In-stent restenosis after revascularization of myocardium with drug-eluting stents is accompanied by elevated level of blood plasma eosinophil cationic protein
In-stent restenosis after revascularization of myocardium with drug-eluting stents is accompanied by elevated level of blood plasma eosinophil cationic protein
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DOI：
10.1139/y11-038
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发表时间：
2011-06-01
影响因子：
2.1
通讯作者：
Smirnov, Vladimir N.
中科院分区：
文献类型：
--
作者：
Gabbasov, Zufar A.;Kozlov, Sergei G.;Smirnov, Vladimir N.
本研究旨在探讨嗜酸性粒细胞阳离子蛋白在药物洗脱支架置入术后支架内再狭窄中的作用。对32例接受经皮冠状动脉介入治疗并植入西罗莫司洗脱支架的患者进行6~12个月的随诊血管造影。采用酶联免疫吸附试验检测血浆嗜酸性粒细胞阳离子蛋白(ECP)和总免疫球蛋白E(IgE)水平，高敏比浊法测定C反应蛋白(hs-CRP)水平。根据血管造影资料，13例发生支架内再狭窄，19例未发生支架内再狭窄。冠脉再狭窄组与无再狭窄组hs-CRP、IgE水平差异无统计学意义。而有再狭窄的患者血清ECP水平明显高于无再狭窄的患者[分别为17.7 ng/mL(11.2~24.0)和9.0 ng/mL(6.4~12.9)，P=0.017]。ECP水平高于或等于11 ng/m L者支架内再狭窄发生率为63%，低于11 ng/m L者为19%(p=0.019)。提示嗜酸性粒细胞活化可能在药物洗脱支架置入后支架内再狭窄的发病机制中起重要作用。
The aim of this study was to assess the involvement of eosinophil cationic protein, a marker of eosinophil activation, in the development of in-stent restenosis after drug-eluting stent implantation. Follow-up angiography at 6 to 12 months was performed in 32 patients who were treated with percutaneous coronary intervention and implantation of sirolimus-eluting stents. Blood plasma levels of eosinophil cationic protein (ECP) and total immunoglobulin E (IgE) were measured by enzyme-linked immunosorbent assay and the level of C-reactive protein (hs-CRP) by high-sensitivity nephelometry. According to angiography data, in-stent restenosis occurred in 13 patients, while 19 patients did not develop it. There were no differences between the hs-CRP and IgE levels in patients with or without restenosis. In contrast, ECP level was higher in patients with restenosis compared with that in patients without restenosis [17.7 ng/mL (11.2-24.0) vs. 9.0 ng/mL (6.4-12.9), p = 0.017]. The incidence of in-stent restenoses was 63% in patients with ECP level higher than or equal to 11 ng/mL, and 19% in patients with an ECP level lower than 11 ng/mL (p = 0.019). These findings suggest that elevated eosinophil activation may play an important role in the pathogenesis of in-stent restenosis after implantation of drug-eluting stents.