Ossification of the human fetal basicranium.
Ossification of the human fetal basicranium.
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人类胎儿骨骨的骨化。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
I. Kjaer
中科院分区：
文献类型：
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作者：
I. Kjaer
以前对人类颅骨的产前发育的研究还没有确定其骨化的顺序。本研究的目的是阐明枕骨大孔前正中矢状区颅骨的骨骼成熟模式。本研究是基于对73例胎儿颅底正中矢状面组织块的放射学和组织化学研究，这些胎儿来自产前前半期。本文观察到人颅骨正中矢状部的骨化模式有明显的规律性。骨化从额骨开始。下一个骨骼骨化的顺序是枕骨、基蝶骨、前蝶骨和筛骨。材料分为7个成熟阶段，设计用于此分析。这些阶段与一般胎儿大小（顶臀长度）和一般胎儿成熟度（手和脚骨化骨的复合数量）有关。人类颅骨中部的颅骨发育与胎儿的大小或一般成熟阶段没有严格的相关性。了解正常骨骼发育对于了解发育异常是必要的。
Previous investigations of prenatal development of the human cranium have not identified the sequence of its ossification. The purpose of the present study was to elucidate the pattern of skeletal maturity of the cranial bones in the midsagittal region anterior to the foramen magnum. This study is based upon a radiographic and histochemical investigation of midsagittal tissue blocks of the cranial bases of 73 human fetuses derived from the first half of the prenatal period. A marked regularity in the ossification pattern of the bones in the midsagittal part of the human cranium was observed. Ossification starts in the frontal bone. The sequence in which the next bones ossify is occipital bone, basisphenoid bone, presphenoid bone, and ethmoid bone. The material was divided into 7 maturity stages devised for this analysis. The stages were related to general fetal size (crown-rump length) and to general fetal maturation (composite number of ossified bones in hand and foot). Skeletal development of the median part of the human cranium is not strictly correlated with the size or the stage of general maturation of the fetuses. Knowledge of normal skeletal development is necessary for understanding anomalies of development.