Rod photoreceptor maturation does not vary with retinal eccentricity in mammalian retina.
Rod photoreceptor maturation does not vary with retinal eccentricity in mammalian retina.
复制标题
哺乳动物视网膜中视杆细胞感光器的成熟不随视网膜偏心率的变化而变化。
DOI：
10.1076/ceyr.18.6.393.5263
复制
发表时间：
1999
影响因子：
2
通讯作者：
Fulton,AB
中科院分区：
文献类型：
--
作者：
Timmers,AM;Fox,DA;He,L;Hansen,RM;Fulton,AB
目的验证哺乳动物视杆细胞外节(ROS)的发育随视网膜偏心率而变化的假说。方法在感光细胞发育过程中，对奶牛和色素沉着大鼠视网膜中央和外周的ROS长度、视蛋白mRNA和(Rhod)视蛋白进行测量。对已发表的白化大鼠、奶牛和猴子的ROS长度和/或视紫红质数据进行了重新分析。Logistic增长曲线与新获得和公布的数据进行了拟合。结果Logistic生长曲线较好地反映了ROS长度、视蛋白mRNA和(Rhod)视蛋白在各视网膜区域的发育过程。在同一物种内，ROS长度、视蛋白mRNA和(Rhod)视蛋白浓度的生长曲线是可叠加的。ROS长度达到成虫值的50%的年龄与偏心率不变。这种模式的一个例外是猿猴的副中凹ROS，它似乎有一个延迟的发育过程。与视杆细胞光感受器细胞发生不同，ROS的发育与视网膜的偏心率是不变的。灵长类的副中窝ROS似乎有不同的发育模式。
PurposeTest the hypothesis that the development of mammalian rod outer segments (ROS) varies with retinal eccentricity.MethodsDuring the period of photoreceptor cell development, ROS lengths, opsin mRNA and (rhod)opsin were measured in central and peripheral retina of cows and pigmented rats. Published ROS length and/or rhodopsin data from albino rats, cows and monkeys were re-analyzed. Logistic growth curves were fitted to the newly obtained and published data. Within a species, growth in central and peripheral regions was compared.ResultsThe logistic growth curves fit all the data well and provide an excellent view of the developmental increases in ROS length, opsin mRNA and (rhod)opsin in each retinal region. Within a species, the growth curves for ROS length, opsin mRNA and (rhod)opsin concentration are superimposable. The age at which ROS length reaches 50% of its adult value is invariant with eccentricity. An exception to this pattern is the simian parafoveal ROS, which appears to have a delayed course of development.ConclusionsThe hypothesis is disproved. Unlike rod photoreceptor cell genesis, ROS development is invariant with retinal eccentricity. Primate parafoveal ROS appear to have a different pattern of development.