Improved pharmacokinetics and enhanced tumor growth inhibition using a nanostructured lipid carrier loaded with doxorubicin and modified with a layer-by-layer polyelectrolyte coating
Improved pharmacokinetics and enhanced tumor growth inhibition using a nanostructured lipid carrier loaded with doxorubicin and modified with a layer-by-layer polyelectrolyte coating
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DOI：
10.1016/j.ijpharm.2015.08.079
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发表时间：
2015-11-10
影响因子：
5.8
通讯作者：
Torchilin, Vladimir P.
中科院分区：
文献类型：
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作者：
Mussi, Samuel V.;Parekh, Gaurav;Torchilin, Vladimir P.
负载阿霉素（DOX）的纳米结构脂质载体（NLC）已被证明对人癌细胞系A549和MCF-7/Adr具有细胞毒性。在试图改善配方特性，提高药代动力学和抗肿瘤作用，我们修改了这些NLC的表面与交替层的聚阳离子和聚阴离子聚电解质（LBL）组件和额外的涂层与PEG使用一个简单的核壳连接的方法。该制剂具有窄的粒度分布、在血液中的停留时间较长、在肝脏中的蓄积较低、在肿瘤中的蓄积较高和显著的肿瘤生长抑制作用。因此，LbL包覆修饰的NLC-DOX纳米制剂复合物具有增强DOX抗肿瘤作用的潜力。(C)2015 Elsevier B. V.版权所有。
A nanostructured lipid carrier (NLC) loaded with doxorubicin (DOX) has been shown to be cytotoxic against the human cancer cell lines A549 and MCF-7/Adr. In attempts to improve formulation characteristics, enhance pharmacokinetics and antitumor effects, we modified the surface of these NLC with an alternating layer-by-layer (LbL) assembly of polycation and polyanion polyelectrolytes and an additional coating with PEG using a simple method of core shell attachment. The formulation had a narrow size distribution, longer residence in the blood, lower accumulation in the liver, higher accumulation in tumors and a significant tumor growth inhibition effect. Thus, NLC-DOX nano-preparations complexes modified by LbL coating have the potential to enhance the anticancer effects of DOX against tumors. (C) 2015 Elsevier B.V. All rights reserved.