Karyotype evolution in a patient with Down syndrome and acute leukemia following a congenital leukemoid reaction.
Karyotype evolution in a patient with Down syndrome and acute leukemia following a congenital leukemoid reaction.
复制标题
先天性类白血病反应后患有唐氏综合症和急性白血病的患者的核型演变。
DOI：
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
D. Becton
中科院分区：
文献类型：
--
作者：
J. Sawyer;G. Roloson;D. Head;D. Becton
We report the serial cytogenetic study of a patient with Down syndrome who experienced a congenital leukemoid reaction, underwent a spontaneous remission within four months, and subsequently developed acute myeloid leukemia at 16 months. A blood chromosome study to rule out Down syndrome performed at age 24 days, during the leukemoid reaction, revealed a 47,XX,+21 karyotype. The diagnosis of acute leukemia was made at 16 months, at which time a chromosome study, on bone marrow, was performed. This analysis revealed a clonal karyotype of 47,XX,+21,-22,+der(22)t(1;22)(q21;q13) in all but one cell studied. The single apparently nonclonal cell showed a karyotype of 49,XX,+12,-13,-19,+der(19)t(19;?)(q11;?)x2,+21,+22. A third chromosome study at 19 months indicated the original leukemic clone with t(1;22) (q21;q13) had been replaced by the clone represented by the single cell with 49 chromosomes seen in the previous chromosome study. This case of an infant with Down syndrome and acute leukemia illustrated rapid evolution and a transitory nature to clonal chromosome aberrations while retaining AML morphology and course.
唐氏综合症急性白血病的染色体线索。
影响因子：
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作者：
Hecht,F;Hecht,BK;Morgan,R;Sandberg,AA;Link,MP
通讯作者：
Link,MP
患有唐氏综合症的白血病：短暂性先天性骨髓增殖综合症后急性粒单核细胞白血病中 1 号和 19 号染色体之间的易位。
影响因子：
20.3
作者：
Morgan,R;Hecht,F;Cleary,ML;Sklar,J;Link,MP
通讯作者：
Link,MP
唐氏综合症中的急性巨核细胞白血病：病例报告和细胞遗传学研究结果回顾。
DOI：
10.1002/mpo.2950130413
发表时间：
1985
期刊：
Medical and pediatric oncology
影响因子：
--
作者：
Suarez,CR;LeBeau,MM;Silberman,S;Fresco,R;Rowley,JD
通讯作者：
Rowley,JD