The current Salmonella-host interactome.
The current Salmonella-host interactome.
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DOI：
10.1002/prca.201100083
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发表时间：
2012-01
影响因子：
2
通讯作者：
Klein-Seetharaman, Judith
中科院分区：
文献类型：
--
作者：
Schleker, Sylvia;Sun, Jingchun;Raghavan, Balachandran;Srnec, Matthew;Mueller, Nicole;Koepfinger, Mary;Murthy, Leelavati;Zhao, Zhongming;Klein-Seetharaman, Judith
Salmonella bacteria cause millions of infections and thousands of deaths every year. This pathogen has an unusually broad host range including humans, animals, and even plants. During infection, Salmonella expresses a variety of virulence factors and effectors that are delivered into the host cell triggering cellular responses through protein–protein interactions (PPIs) with host cell proteins which make the pathogen’s invasion and replication possible. To speed up proteomic efforts in elucidating Salmonella–host interactomes, we carried out a survey of the currently published Salmonella–host PPI. Such a list can serve as the gold standard for computational models aimed at predicting Salmonella–host interactomes through integration of large-scale biological data sources. Manual literature and database search of >2200 journal articles and >100 databases resulted in a gold standard list of currently 62 PPI, including primarily interactions of Salmonella proteins with human and mouse proteins. Only six of these interactions were directly retrievable from PPI databases and 16 were highlighted in databases featuring literature extracts. Thus, the literature survey resulted in the most complete interactome available to date for Salmonella. Pathway analysis using Ingenuity and Broad Gene Set Enrichment Analysis (GSEA) software revealed among general pathways such as MAPK signaling in particular those related to cell death as well as cell morphology, turnover, and interactions, in addition to response to not only Salmonella but also other pathogenic – viral and bacterial – infections. The list of interactions is available at http://www.shiprec.org/indicationslist.htm
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影响因子：
6.1
作者：
Carlson, SA;Omary, MB;Jones, BD
通讯作者：
Jones, BD
影响因子：
3.7
作者：
Dyer MD;Neff C;Dufford M;Rivera CG;Shattuck D;Bassaganya-Riera J;Murali TM;Sobral BW
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Sobral BW
影响因子：
16.8
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Diao, Jianbo;Zhang, Ying;Chen, Jue
通讯作者：
Chen, Jue
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Cheminay, C;Möhlenbrink, A;Hensel, M
通讯作者：
Hensel, M
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4.8
作者：
Diacovich, Lautaro;Dumont, Audrey;Meresse, Stephane
通讯作者：
Meresse, Stephane