Evidence regarding clinical use of microvolt T-wave alternans
Evidence regarding clinical use of microvolt T-wave alternans
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DOI：
10.1016/j.hrthm.2008.10.011
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发表时间：
2009-03-01
期刊：
影响因子：
5.5
通讯作者：
Cohen, Richard J.
中科院分区：
文献类型：
--
作者：
Hohnloser, Stefan H.;Ikeda, Takanori;Cohen, Richard J.
背景许多研究证明，微伏T波电交替（MTWA）测试是具有心源性猝死（SCD）风险因素但无持续性VTE既往史（一级预防患者）的室性心动过速事件（VTE）的高度准确预测因子。在最近的一些研究中，涉及一级预防患者植入心脏复律除颤器（ICD），MTWA没有表现以及objectives.Objective这项研究检查的假设，MTWA是一个准确的预测VTE的一级预防患者没有植入ICD，但在植入ICD的患者中不适合ICD治疗。方法本研究确定了前瞻性临床试验，频谱分析方法在一级预防人群中的应用，并分析了以下研究：（1）很少有患者植入ICD，因此没有或只有一小部分患者（
BACKGROUND Microvolt T-wave alternans (MTWA) testing in many studies has proven to be a highly accurate predictor of ventricular tachyarrhythmic events (VTEs) in patients with risk factors for sudden cardiac death (SCD) but without a prior history of sustained VTEs (primary prevention patients). In some recent studies involving primary prevention patients with prophylactically implanted cardioverter-defibrillators (ICDs), MTWA has not performed as well.OBJECTIVE This study examined the hypothesis that MTWA is an accurate predictor of VTEs in primary prevention patients without implanted ICDs, but not of appropriate ICD therapy in Such patients with implanted ICDs.METHODS This study identified prospective clinical trials evaluating MTWA measured using the spectral analytic method in primary prevention populations and analyzed studies in which: (1) few patients had implanted ICDs and as a result none or a small fraction (