Early life phthalate exposure and atopic disorders in children: A prospective birth cohort study
Early life phthalate exposure and atopic disorders in children: A prospective birth cohort study
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DOI：
10.1016/j.envint.2013.09.002
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发表时间：
2014-01-01
影响因子：
11.8
通讯作者：
Chen, Pau-Chung
中科院分区：
文献类型：
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作者：
Wang, I-Jen;Lin, Ching-Chun;Chen, Pau-Chung
邻苯二甲酸酯暴露在免疫系统和特应性疾病的不同阶段的作用尚不清楚。本研究旨在通过客观生物标志物评估产前和产后邻苯二甲酸酯暴露对儿童免疫球蛋白E（IgE）水平和特应性皮炎（AD）的影响。我们进行了一项前瞻性台湾出生面板队列研究，共有483对母亲/婴儿。最后，在排除缺失数据和失访后，分析了161份妊娠晚期尿液标本、219份2岁儿童尿液标本和192份5岁尿液标本。采用超高效液相色谱-串联质谱法测定妊娠晚期、2岁和5岁孕妇尿中邻苯二甲酸单乙酯（MEP）、邻苯二甲酸单丁酯（MBP）、邻苯二甲酸单苄酯（MBzP）和邻苯二甲酸单（2-乙基己基）酯（MEHP）的含量。在2岁和5岁时，收集关于AD发展和血清总IgE的信息。采用多元线性回归和Logistic回归分析不同阶段尿邻苯二甲酸酯代谢产物水平与血清IgE和AD的关系。2岁时尿邻苯二甲酸酯代谢物水平高于妊娠期和5岁时。在每个时期，尿MBP水平均高于MEP、MEHP和MBzP。2岁时的MEHP水平与血清IgE水平正相关（每单位：β = 0.191，p = 0.02）。按性别分层的分析显示，MEHP水平仅在男孩中与血清IgE水平呈正相关（每单位：β = 0.256，p = 0.03）。当分成四分位数时，2岁时的尿MBzP水平与AD有显著相关性。我们发现其他邻苯二甲酸酯代谢物与IgE和AD没有统计学显着相关性。早期邻苯二甲酸酯暴露可能会增加过敏性致敏和特应性疾病的风险。(C)2013爱思唯尔有限公司保留所有权利。
The role of phthalate exposure at different stages in the immune system and atopic disorders is not well-known. This study aims to evaluate the effects of prenatal and postnatal phthalate exposures on immunoglobulin E (IgE) levels and atopic dermatitis (AD) in children by objective biomarkers. We conducted a prospective Taiwan Birth Panel cohort study with 483 mother/infant pairs. Finally, 161 urine specimens at 3rd trimester of pregnancy, 219 urine specimens from children at age 2, and 192 urine specimens at age 5 were analyzed after excluding missing data and loss to follow-up. Urine monoethyl phthalate (MEP), monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), and mono-(2-ethylhexyl) phthalate (MEHP) at 3rd trimester of pregnancy and at ages 2 and 5 were measured by ultra-performance liquid chromatography coupled with tandem mass spectrometry. At ages 2 and 5, information on the development of AD and serum total IgE was collected. The association between urine phthalate metabolite levels at different stages and serum IgE and AD was evaluated by multivariate linear regression and logistic regression. Urine phthalate metabolite levels were higher at age 2 than those at pregnancy and age 5. At each period, urine MBP levels were higher than MEP, MEHP, and MBzP. MEHP levels at age 2 positively correlated with serum IgE levels (per In-unit: beta = 0.191, p = 0.02). Analyses stratified by gender revealed that MEHP levels positively correlated with serum IgE levels only in boys (per ln-unit: beta = 0.256, p = 0.03). When dividing into quartiles, urine MBzP levels at age 2 had a significant association with AD. We found no statistically significant association of other phthalate metabolites with IgE and AD. Early life phthalate exposure may increase the risk of allergic sensitization and atopic disorders. (C) 2013 Elsevier Ltd. All rights reserved.