The importance of dietary modulation of cAMP and insulin signaling in adipose tissue and the development of obesity
The importance of dietary modulation of cAMP and insulin signaling in adipose tissue and the development of obesity
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DOI：
10.1111/j.1749-6632.2009.05262.x
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Kristiansen, Karsten
中科院分区：
文献类型：
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作者：
Madsen, Lise;Kristiansen, Karsten
脂肪组织在全身能量平衡中起着关键作用。在这篇综述中，我们总结了胰岛素和环磷酸腺苷（cAMP）信号在脂肪细胞分化和功能中看似矛盾的作用的知识，强调cAMP信号的两个分支之间的相互作用，典型的蛋白激酶A依赖的途径和新的交换蛋白激活的cAMP（Epac）依赖的途径，和胰岛素信号。我们讨论了大量营养素如何通过改变胰岛素和cAMP依赖性信号之间的平衡来影响肥胖的发展，通过改变能量消耗和/或饲料效率。我们回顾的结果表明，不同类别的碳水化合物和蛋白质之间的平衡如何调节的obesigenic行动的饱和和不饱和脂肪酸指向胰岛素作为一个关键的决定因素，在调节的代谢/调节行动的n-3和n-6多不饱和脂肪酸。
Adipose tissue plays a pivotal role in whole body energy homeostasis. In this review, we summarize knowledge of the seemingly paradoxical roles of insulin and cyclic adenosine monophosphate (cAMP) signaling in adipocyte differentiation and function, emphasizing the interplay between the two branches of cAMP signaling, the canonical protein kinase A-dependent pathways and the novel exchange protein activated by cAMP (Epac)-dependent pathways, and insulin signaling. We discuss how macronutrients via changes in the balance between insulin- and cAMP-dependent signaling can affect the development of obesity by changing energy expenditure and/or feed efficiency. We review results demonstrating how the balance between different classes of carbohydrates and proteins modulates the obesigenic action of saturated as well as unsaturated fatty acids pointing to insulin as a key determinant in the regulation of the metabolic/regulatory action of both n-3 and n-6 polyunsaturated fatty acids.