A TRITHORAX-LIKE GENE IS INTERRUPTED BY CHROMOSOME 11Q23 TRANSLOCATIONS IN ACUTE LEUKEMIAS
A TRITHORAX-LIKE GENE IS INTERRUPTED BY CHROMOSOME 11Q23 TRANSLOCATIONS IN ACUTE LEUKEMIAS
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DOI：
10.1038/ng1092-113
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发表时间：
1992-10-01
期刊：
影响因子：
30.8
通讯作者：
EVANS, GA
中科院分区：
文献类型：
--
作者：
DJABALI, M;SELLERI, L;EVANS, GA
Some acute lymphocytic leukaemias, particularly those in young children, are associated with a t(4;11)(q21;q23) reciprocal translocation. We have cloned the translocation breakpoint on chromosome 11q23 and isolated corresponding RNA transcripts from this region. The translocation occurs within a cluster of Alu repetitive elements located within an intron of a gene that gives rise to 11.5 (kb) transcript spanning the translocation breakpoint. The 11.5 kb transcript encodes a protein that is highly homologous to the Drosophila trithorax gene, a developmental regulator. An analysis of a series of leukaemic patients carrying t(4;11) and t(9;11) translocations indicate that the majority of breakpoints in infant leukaemias lie within a 5 kb region.
