Longer-term mortality following SARS-CoV-2 infection in people with severe mental illness: retrospective case-matched study.

Longer-term mortality following SARS-CoV-2 infection in people with severe mental illness: retrospective case-matched study.
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DOI:
10.1192/bjo.2021.1046
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发表时间:
2021-11
期刊:
影响因子:
5.4
通讯作者:
Cardinal RN
Cardinal RN
中科院分区:
医学3区
文献类型:
--
作者:
Chen S;Fernandez-Egea E;Jones PB;Lewis JR;Cardinal RN

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在SARS-CoV-2感染后,经常观察到持续的症状和功能障碍。然而,关于COVID-19后果的信息并不充分。我们对感染SARS-CoV-2的严重精神疾病(SMI)患者进行了随访,并使用英国剑桥郡和彼得伯勒NHS基金会信托基金的数据评估了他们的长期死亡率。我们从诊断的角度检查了死亡风险的时间过程和持续时间。SARS-CoV-2感染后,重度精神分裂症患者的死亡风险显著增加(风险比(HR) = 5.16, 95%置信区间(CI) 1.56-17.03;P = 0.007),在前28天和随后的28 - 60天(HR = 2.96, 95% CI 1.21-7.26; P = 0.018),但在60天后,死亡的额外风险不再显著(HR = 2.33, 95% CI 0.83-6.53; P = 0.107)。
Persisting symptoms and dysfunction after SARS-CoV-2 infection have frequently been observed. However, information on the aftermath of COVID-19 is inadequate. We followed up people with severe mental illness (SMI) infected with SARS-CoV-2, and evaluated their longer-term mortality, using data from Cambridgeshire and Peterborough NHS Foundation Trust, UK. We examined the time course and duration of mortality risk from the point of diagnosis. After SARS-CoV-2 infection, people with SMI had a substantially higher risk of death (hazard ratio (HR) = 5.16, 95% confidence interval (CI) 1.56–17.03; P = 0.007) during the first 28 days and during the following 28–60 days (HR = 2.96, 95% CI 1.21–7.26; P = 0.018) than those without infection, but after 60 days the additional risk of death was no longer significant (HR = 2.33, 95% CI 0.83–6.53; P = 0.107).
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