Connectivity-based parcellation of the thalamus in multiple sclerosis and its implications for cognitive impairment: A multicenter study
Connectivity-based parcellation of the thalamus in multiple sclerosis and its implications for cognitive impairment: A multicenter study
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DOI：
10.1002/hbm.22809
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发表时间：
2015-07-01
影响因子：
4.8
通讯作者：
Filippi, Massimo
中科院分区：
文献类型：
--
作者：
Bisecco, Alvino;Rocca, Maria A.;Filippi, Massimo
在这项多中心研究中，我们对多发性硬化症（MS）患者的丘脑及其白质连接进行了基于神经束造影的包裹，以研究丘脑连接异常与认知障碍之间的关系。收集了来自欧洲6个中心的52名复发缓解型MS患者和57名健康对照者的双回声、形态和扩散张量（DT）磁共振成像（MRI）扫描结果。患者接受了广泛的神经心理学评估。基于丘脑连接定义区（cdr）的皮质连通性，采用基于扩散束图的分割方法对其进行分割。比较CDRs和皮质丘脑束DT MRI指标的组间差异。还进行了丘脑形状的顶点分析。随机森林分析用于确定全局认知损伤和特定认知域缺陷的最佳影像学预测因子。22例（43%）MS患者存在认知障碍（CI）。与认知保留患者相比，CI MS患者额叶、运动、后中枢和枕部连接cdr的分数各向异性增加（0.002）
In this multicenter study, we performed a tractography-based parcellation of the thalamus and its white matter connections to investigate the relationship between thalamic connectivity abnormalities and cognitive impairment in multiple sclerosis (MS). Dual-echo, morphological and diffusion tensor (DT) magnetic resonance imaging (MRI) scans were collected from 52 relapsing-remitting MS patients and 57 healthy controls from six European centers. Patients underwent an extensive neuropsychological assessment. Thalamic connectivity defined regions (CDRs) were segmented based on their cortical connectivity using diffusion tractography-based parcellation. Between-group differences of CDRs and cortico-thalamic tracts DT MRI indices were assessed. A vertex analysis of thalamic shape was also performed. A random forest analysis was run to identify the best imaging predictor of global cognitive impairment and deficits of specific cognitive domains. Twenty-two (43%) MS patients were cognitively impaired (CI). Compared to cognitively preserved, CI MS patients had increased fractional anisotropy of frontal, motor, postcentral and occipital connected CDRs (0.002