Macrophage-Mediated Porous Magnetic Nanoparticles for Multimodal Imaging and Postoperative Photothermal Therapy of Gliomas.
Macrophage-Mediated Porous Magnetic Nanoparticles for Multimodal Imaging and Postoperative Photothermal Therapy of Gliomas.
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DOI：
10.1021/acsami.1c12406
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发表时间：
2021-11
影响因子：
9.5
通讯作者：
Sheng Wang;Hailin Shen;Qiulian Mao;Qing Tao;Guotao Yuan;Lingli Zeng;Ziying Chen;Yunjiao Zhang-Yunjiao
中科院分区：
文献类型：
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作者：
Sheng Wang;Hailin Shen;Qiulian Mao;Qing Tao;Guotao Yuan;Lingli Zeng;Ziying Chen;Yunjiao Zhang-Yunjiao
由于血脑屏障和胶质瘤细胞的高度浸润性，胶质瘤的诊断准确性和治疗效率仍面临挑战。迫切需要探索诊断和治疗方法的整合，以实现准确诊断，指导手术，抑制术后复发。在这项工作中，我们开发了一种装载有光热纳米探针（MFe 3 O 4-Cy5.5）的巨噬细胞，它能够穿过血脑屏障并积聚到深部胶质瘤中，以实现多模式成像和指导胶质瘤手术的目的。Fe 3 O 4-Cy 5. 5具有良好的探测深度和高信噪比，可进行荧光、光声和磁共振成像，可将脑肿瘤与周围正常组织区分开来，准确指导胶质瘤切除。同时，Fe 3 O 4-Cy5.5能有效诱导局部光热治疗，抑制胶质瘤术后复发。这些结果表明，巨噬细胞介导的Fe 3 O 4-Cy 5. 5，可以实现多模式诊断，准确的成像引导手术，有效的光热治疗，是一个有前途的神经胶质瘤纳米平台。
Because of the blood-brain barrier and the high infiltration of glioma cells, the diagnostic accuracy and treatment efficiency of gliomas are still facing challenges. There is an urgent need to explore the integration of diagnostic and therapeutic methods to achieve an accurate diagnosis, guide surgery, and inhibit postoperative recurrence. In this work, we developed a macrophage loaded with a photothermal nanoprobe (MFe3O4-Cy5.5), which is able to cross the blood-brain barrier and accumulate into deep gliomas to achieve multimodal imaging and guided glioma surgery purposes. With desirable probing depth and high signal-to-noise ratio, Fe3O4-Cy5.5 can perform fluorescence, photoacoustic, and magnetic resonance imaging, which can distinguish brain tumors from the surrounding normal tissues and accurately guide glioma resection. Meanwhile, Fe3O4-Cy5.5 can effectively induce local photothermal therapy and inhibit the recurrence of glioma after surgery. These results demonstrate that the macrophage-mediated Fe3O4-Cy5.5, which can achieve a multimodal diagnosis, accurate imaging-guided surgery, and effective photothermal therapy, is a promising nanoplatform for gliomas.