Inositol phospholipids are probably not the source of arachidonic acid for eicosanoid synthesis in astrocytes
Inositol phospholipids are probably not the source of arachidonic acid for eicosanoid synthesis in astrocytes
复制标题
肌醇磷脂可能不是星形胶质细胞中合成类二十烷酸的花生四烯酸的来源
DOI:
10.1016/0014-5793(87)81277-2
复制
发表时间:
1987
期刊:
影响因子:
3.5
通讯作者:
P. Dandona
中科院分区:
文献类型:
--
作者:
B. Pearce;J. Jeremy;C. Morrow;S. Murphy;P. Dandona
In astrocyte-enriched cultures of the rat cerebral cortex the Ca2+ionophore A23187 provoked the breakdown of inositol phospholipids, the liberation of arachidonic acid and the release of prostaglandins E2, F2α, I2and thromboxane A2. However, agonists for receptors also coupled to inositol phospholipid metabolism in these cells failed to produce an increase in the release of both arachidonic acid and eicosanoids. Results suggest that the A23187-stimulated release of arachidonic acid and eicosanoids is caused by a phospholipase A2-mediated attack on lipids other than the inositol phospholipids. Moreover, receptors linked to inositol lipid turnover are not involved in the control of eicosanoid release from astrocytes.
登录
查看更多内容
DOI:
10.1016/0090-6980(84)90025-x
发表时间:
1984
期刊:
Prostaglandins
影响因子:
--
作者:
Yousufzai,SY;Abdel-Latif,AA
通讯作者:
Abdel-Latif,AA
DOI:
10.1042/bj2360235
发表时间:
1986
期刊:
The Biochemical journal
影响因子:
--
作者:
Dudley,DT;Spector,AA
通讯作者:
Spector,AA
DOI:
--
发表时间:
1986
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
DeGeorge,JJ;Morell,P;McCarthy,KD;Lapetina,EG
通讯作者:
Lapetina,EG
DOI:
--
发表时间:
1984
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
Kolesnick,RN;Gershengorn,MC
通讯作者:
Gershengorn,MC