Serum apolipoprotein E concentration and polymorphism influence serum lipid levels in Chinese Shandong Han population.
Serum apolipoprotein E concentration and polymorphism influence serum lipid levels in Chinese Shandong Han population.
复制标题
血清载脂蛋白E浓度和多态性影响中国山东汉族的血清脂质水平。
DOI：
10.1097/md.0000000000005639
复制
发表时间：
2016-12
期刊：
影响因子：
1.6
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Han S;Xu Y;Gao M;Wang Y;Wang J;Liu Y;Wang M;Zhang X
载脂蛋白E（ApoE）可与多种脂质结合，在脂质和脂蛋白的代谢和稳态中起重要作用，可影响血脂指标。先前的研究表明，ApoE浓度显着影响血脂水平独立于ApoE多态性。血脂水平也与饮食习惯密切相关，鲁菜以其高盐和高油含量而闻名，这在中国不同地区之间存在很大差异。因此，研究ApoE基因多态性对山东地区人群ApoE浓度和血脂水平的影响具有重要意义。从山东省济南市随机抽取815名被试，男285名，女530名。为探讨ApoE基因多态性与血脂水平的关系，检测所有受试者的ApoE基因型、空腹血清ApoE水平及其他血脂指标。ApoE基因E3等位基因频率最高（83.1%），E2和E4等位基因频率分别为9.4%和7.5%。ApoE 2等位基因携带者的ApoE水平显著升高，但血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和载脂蛋白B（ApoB）水平降低。我们发现ApoE水平受ApoE基因多态性的影响。ApoE基因多态性对山东汉族人群血脂指标的影响随年龄和体重指数的增加而不同。
Apolipoprotein E (ApoE), which has been shown to influence serum lipid parameters, can bind to multiple types of lipids and plays an important role in the metabolism and homeostasis of lipids and lipoproteins. A previous study showed that ApoE concentration significantly affects serum lipid levels independently of ApoE polymorphism. The serum lipid levels were also closely correlated with dietary habits, and Shandong cuisine is famous for its high salt and oil contents, which widely differ among the different areas in China. Therefore, studying the effect of ApoE polymorphism on ApoE concentration and serum lipid levels in Shandong province is very important. A total of 815 subjects including 285 men and 530 women were randomly selected and studied from Jinan, Shandong province. In order to evaluate the association of ApoE polymorphism and serum level on lipid profiles, the ApoE genotypes, as well as levels of fasting serum ApoE and other lipid parameters, were detected in all subjects. The frequency of the ApoE E3 allele was highest (83.1%), while those of E2 and E4 were 9.4% and 7.5%, respectively, which are similar to those in other Asian populations. ApoE2 allele carriers showed significantly increased ApoE levels but lower levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and Apolipoprotein B (ApoB). We found that ApoE level is influenced by ApoE polymorphism in a gene-dependent manner. The ApoE polymorphism showed different influences on serum lipid parameters with increasing age and body mass index (BMI) in our Shandong Han population.