Cytologic alterations in the anterior pituitary gland following thyroidectomy: an electron microscope study.
Cytologic alterations in the anterior pituitary gland following thyroidectomy: an electron microscope study.
复制标题
甲状腺切除术后垂体前叶的细胞学改变：电子显微镜研究。
作者：
M. Farquhar;J. F. Rinehart
前言在对大鼠垂体前叶细胞学进行详细研究的过程中，对一系列大鼠进行了甲状腺切除手术。很快就很明显，某些嗜碱性粒细胞发生了一种独特的特征的变化，这有助于将它们与性腺切除所刺激的嗜碱性粒细胞区分开来。性腺切除后发生的特有的细微结构变化已被详细描述(Farquhar和Rinehart，1954)。对甲状腺切除的早期反应的检查使我们能够识别正常动物中未受刺激的促甲状腺细胞。本报告的目的是指出该细胞的精细结构组织及其对甲状腺切除的反应，并将其与正常动物和去势动物的促性腺激素进行比较。Purves和Griesbach(1951a，b)和Halmi(1950和1952)的研究在我们认识促甲状腺激素方面起到了重要的指导作用。
INTRODUCTION IN THE course of a detailed study of the cytology of the anterior pituitary gland as revealed by electron microscopy, a series of rats were subjected to thyroidectomy. It soon became evident that alterations of a distinctive character occurred in certain of the basophils which served to distinguish them from the basophils stimulated by gonadectomy. The characteristic fine structural alterations which occur following gonadectomy have been described in detail (Farquhar and Rinehart, 1954). Examination of the early response to thyroidectomy has enabled us to recognize the unstimulated thyrotrophic cell in the normal animal. It is the purpose of this report to indicate the fine structural organization of this cell and its response to thyroidectomy as well as to contrast it with the gonadotroph of the normal animal and the castrate. The studies of Purves and Griesbach (1951a, b) and Halmi (1950 and 1952) have served importantly as guides in our recognition of the thyrotroph.