The why's and wherefore's of this vascular biology section of Current Opinion in Hematology.
The why's and wherefore's of this vascular biology section of Current Opinion in Hematology.
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《当前血液学观点》的血管生物学部分的原因和原因。
DOI：
10.1097/moh.0000000000000242
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发表时间：
2016
影响因子：
3.2
通讯作者：
Plow,EdwardF
中科院分区：
文献类型：
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作者：
Plow,EdwardF
这是我第一次尝试组织一期《血液学当前观点》，事实上，也是我第一次尝试组织任何可比的文章汇编。当主编汤姆·斯托塞尔（Tom Stossel）招募我组织“血管生物学”部分时，他说这将是我做过的最简单的工作。不完全正确，但不是一个困难的工作，当然是一个愉快的任务。第一个任务是确定一个主题。人们可以选择专注于一个单一的主题，并深入研究。这就需要成功地从一批具有高度专业兴趣的作者中征聘，并可能导致文章大量重叠。所以，我决定一个更广泛的主题是为了。当然，“内皮”是“血管生物学”部分的安全选择.本期《血液学当前观点》的八篇文章中的每一篇都涉及内皮的某些方面。作者被赋予了一个主题，从他们的专业领域，并要求提供最新的观点，在特定的分子，信号通路，和/或机制在这一领域的重点发展，在过去的一年。有一个统一的主题，连接所有八篇文章。它们处理内皮细胞与其环境之间的通信。这种沟通是双向的。借用整合素领域中常用的术语，信号通路可以是“由外向内”和“由内而外”。由外向内信号通过内皮细胞表面上的受体产生。这些受体的例子是蛋白酶激活受体-1，由Grimsey和Trejo（pp. 274-279），和neuropilin，讨论了Kofler和Simons（pp. 260-267）。这些受体识别内皮细胞微环境中的配体，这些配体参与由外向内的信号传导事件。内皮细胞还可以吸附来自肿瘤的外来体，所述外来体注入可以影响细胞内反应（包括血管生成）的微RNA和其他信息分子，如Ohyashiki（pp. 268-273）在他的文章。内皮细胞在其细胞外位置感知血流和壁切应力的变化
This is my first attempt to organize an issue of Current Opinion in Hematology, and indeed, my first attempt to organize any comparable compilation of articles. When the Editor-in-Chief, Tom Stossel, recruited me to organize the ‘Vascular biology’section, he said it would be the easiest job I had ever done. Not quite true, but not a difficult job, and certainly an enjoyable task. The first task was to decide on a theme. One could choose to focus on a single topic and delve into it in great depth. That would require success in recruiting from a group of authors with a highly specialized interest and could lead to articles with extensive overlap. So, I decided that a broader topic was in order. Certainly,‘the endothelium’was a safe choice for a ‘Vascular biology’section. Each of the eight contributions in this issue of the Current Opinion in Hematology deals with some aspect of the endothelium. The authors were given a topic from within their area of expertise and asked to provide up-to-date perspectives on a particular molecule, signaling pathway, and/or mechanism within this area with an emphasis on developments during the past year.There is a unifying theme that links all eight articles. They deal with the communication between endothelial cells and their environment. This communication is bidirectional. To usurp terms that are used frequently in the integrin field, the signaling pathways can be both ‘outside-in’and ‘inside-out’. Outside-in signals are generated via receptors on the endothelial cell surfaces. These receptors are exemplified by protease-activated receptor-1, described by Grimsey and Trejo (pp. 274–279), and neuropilin, discussed by Kofler and Simons (pp. 260–267). These receptors recognize ligands in the microenvironment of endothelial cells that transduce outside-in signaling events. Endothelial cells can also adsorb exosomes from tumors that infuse microRNA and other informative molecules that can influence intracellular responses including angiogenesis as described by Ohyashiki (pp. 268–273) in his article. Endothelial cells sense changes in blood flow and wall shear stress at their extracellular