Novel pH-responsive nanoparticles
Novel pH-responsive nanoparticles
复制标题
DOI：
10.1021/la801472x
复制
发表时间：
2008-09-02
期刊：
影响因子：
3.9
通讯作者：
Stepanek, Petr
中科院分区：
文献类型：
--
作者：
Filippov, Sergey;Hruby, Martin;Stepanek, Petr
在这项工作中，我们报告了一种新型的pH响应胶束状纳米粒子。可逆的纳米级结构形成在溶液中的pH值敏感的疏水性聚（N-甲基丙烯酰基-L-缬氨酸）或聚（N-甲基丙烯酰基-L-苯丙氨酸），和非离子表面活性剂（Brij 98）在盐酸的存在下。通过多种方法研究了组成和pH对颗粒尺寸和形状的影响。实体的大小和多分散性可以在很宽的范围内变化，使它们成为药物载体的前景候选者。不同于典型的胶束的情况下，我们的研究结果表明，在形成的颗粒中存在空腔。提出了一个假设的纳米粒子模型和形成机制。
In this work we report a new type of pH-responsive micelle-like nanoparticle. Reversible nanoscale structures are formed in solutions of a pH-sensitive hydrophobic polyelectrolyte, poly(N-methacryloyl-L-valine) or poly(N-methacryloyl-L-phenylalanine), and nonionic surfactant (Brij 98) in the presence of hydrochloric acid. The influence of composition and pH on particles size and shape was investigated by a variety of methods. An entity's size and polydispersity could be varied in a broad range making them a perspective candidate as a drug carrier. Unlike the case of typical micelles, our results indicate the presence of cavities in the formed particles. A hypothetical model of a nanoparticle and mechanism of formation are proposed.