Bacteria sensing mechanisms in Drosophila gut: Local and systemic consequences
Bacteria sensing mechanisms in Drosophila gut: Local and systemic consequences
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DOI：
10.1016/j.dci.2016.01.001
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发表时间：
2016-11-01
影响因子：
2.9
通讯作者：
Royet, Julien
中科院分区：
文献类型：
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作者：
Capo, Florence;Charroux, Bernard;Royet, Julien
所有昆虫的外骨骼、肠道，甚至在某些情况下，它们自己的体细胞和生殖细胞内都有微生物定植。这种微生物群可以占昆虫生物量的百分之几，可能对昆虫生物学的许多方面产生广泛影响，包括生理学，营养获取，衰老，行为和抗感染能力。主要通过摄入污染的食物，口-肠轴代表了外部细菌进入宿主的第一个和主要途径。摄食后不久，摄食昆虫需要快速准确地识别摄入的微生物，并决定是否保留它们（如果有益或中性），或者消除它们（如果可能有害）。我们将在这里审查最近在果蝇中获得的无脊椎动物肠上皮细胞依赖于检测肠道中细菌的存在的机制的数据。我们将比较这些细菌传感模式与其他免疫组织中的模式，并试图合理化可能存在的差异。我们还将分析细菌检测的生理后果，不仅对肠道本身，而且对远端组织。最后，我们将描述由于肠道上皮不准确的细菌鉴定而可能发生的生理疾病。(C)2016爱思唯尔有限公司版权所有
All insects are colonized by microorganisms on their exoskeleton, their gut and even in some cases within their own somatic and germ line cells. This microbiota that can represent up to a few percent of the insect biomass may have a pervasive impact on many aspects of insect biology including physiology, nutrient acquisition, ageing, behaviour and resistance to infection. Mainly through ingestion of contaminated food, the mouth-gut axis represents the first and principal access of external bacteria to the host. Soon after ingestion, the feeding insect needs to rapidly and accurately identify the ingested microbes and decide whether to preserve them if beneficial or neutral, or to eliminate them if potentially harmful. We will review here the recent data acquired in Drosophila on the mechanisms that invertebrate enterocytes rely on to detect the presence of bacteria in the gut. We will compare these modes of bacteria sensing to those in other immune competent tissues and try to rationalize differences that may exist. We will also analyse the physiological consequences of bacteria detection not only locally for the gut itself but also for remote tissues. Finally, we will describe the physiological disorders that can occur due to inaccurate bacteria identification by the gut epithelium. (C) 2016 Elsevier Ltd. All rights reserved.