THE UCS PREEXPOSURE EFFECT IN TASTE-AVERSION LEARNING - TOLERANCE AND BLOCKING ARE DRUG SPECIFIC
THE UCS PREEXPOSURE EFFECT IN TASTE-AVERSION LEARNING - TOLERANCE AND BLOCKING ARE DRUG SPECIFIC
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DOI：
10.3758/bf03212052
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
RILEY, AL
中科院分区：
文献类型：
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作者：
DACANAY, RJ;RILEY, AL
药物预暴露后，在预暴露环境或家庭笼子中对大鼠进行味觉厌恶调节。对于预先暴露于LiCl的动物，只有在暴露前环境中调节的受试者表现出典型的UCS[无条件刺激]暴露前效应，即减弱的厌恶，这种效应与LiCl诱导的暴露前效应的阻断解释一致。所有预先暴露于吗啡的大鼠均表现出减弱的厌恶感，与暴露前和调节环境无关，这种效应与 UCS 吗啡暴露前效应的药理学耐受性解释一致。药物引起的减弱的具体机制似乎是药物依赖性的。
Following drug preexposure, rats were given taste aversion conditioning in either the preexposure environment or the home cage. For animals preexposed to LiCl, only the subjects conditioned in the preexposure environment showed the typical UCS [unconditioned stimulus] preexposure effect, that is, an attenuated aversion, an effect consistent with a blocking interpretation of the LiCl-induced preexposure effect. All rats preexposed to morphine displayed attenuated aversions, independent of the preexposure and conditioning environments, an effect consistent with a pharmacological tolerance explanation of the UCS preexposure effect to morphine. The specific mechanism underlying the drug-induced attenuation appears to be drug-dependent.