The role of Muller cells in fibrocontractive retinal disorders
The role of Muller cells in fibrocontractive retinal disorders
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DOI：
10.1016/j.preteyeres.2004.07.001
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发表时间：
2005-01-01
影响因子：
17.8
通讯作者：
Guidry, C
中科院分区：
文献类型：
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作者：
Guidry, C
尽管在纤维收缩性视网膜疾病的手术治疗方面取得了进展，但增殖性玻璃体视网膜病变（PVR）和增殖性糖尿病视网膜病变（PDR）仍然是失明的主要原因，并且对于所涉及的细胞类型的起源和作用仍然存在相当大的不确定性。Muller细胞和被鉴定为视网膜神经胶质的细胞在来自两种类型的病症的视网膜前组织中一致地被鉴定。然而，它们相对于总细胞群的丰度通常较低，使它们在这些疾病中的作用不确定。使用组织培养和动物模型的Muller细胞生物学研究提供了这种细胞类型对环境损伤的分级反应的显著能力、增殖、从视网膜移位和改变表型以及因此改变功能特征的能力的证据。本文综述了Muller细胞在纤维收缩性视网膜疾病中的潜在作用，特别是Muller细胞在PVR和PDR相关的牵引性视网膜脱离中作为效应细胞发挥作用的证据。(C)2004 Elsevier Ltd.保留所有权利。
Despite advances in surgical management of fibrocontractive retinal disorders, proliferative vitreoretinopathy (PVR) and proliferative diabetic retinopathy (PDR) remain major causes of blindness and there is still considerable uncertainty about the origins and roles of the cell types involved. Muller cells and cells identified as retinal glia are consistently identified in epiretinal tissues from both types of disorders. However, their abundance relative to total cell populations is generally low, leaving their role in these disorders uncertain. Studies of Muller cell biology using tissue culture and animal models provide evidence of the remarkable capacity of this cell type for graded responses to environmental insult, the capacity to proliferate, translocate from the retina and alter phenotype and thus, functional characteristics. This review considers the potential roles of Muller cells in fibrocontractive retinal disorders and, in particular, evidence that Muller cells function as an effector cell type in traction retinal detachment associated with PVR and PDR. (C) 2004 Elsevier Ltd. All rights reserved.