C-Reactive Protein Gene Variants in Depressive Symptoms & Antidepressants Efficacy
C-Reactive Protein Gene Variants in Depressive Symptoms & Antidepressants Efficacy
复制标题
抑郁症状中的 C 反应蛋白基因变异
DOI：
10.30773/pi.2019.0117
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发表时间：
2019-12-01
影响因子：
2.7
通讯作者：
Zhang, Kerang
中科院分区：
文献类型：
--
作者：
Li, Xinxin;Sun, Ning;Zhang, Kerang
目的抑郁症的发病机制尚不清楚，但抑郁症患者的C反应蛋白(CRP)水平普遍升高。因此，影响C反应蛋白水平的C反应蛋白单核苷酸多态(SNP)可能与抑郁症有关。在本研究中，我们探讨了CRPSNPs是否与中国汉族患者的抑郁症状和抗抑郁药物疗效相关。方法对440例首发抑郁症患者的临床资料进行分析。分别在基线和6周后进行基因组C反应蛋白SNPs、汉密尔顿17项抑郁评定量表(HAMD17)及其4个因子的评分。采用非阶段性软件进行数量性状分析，采用SPSS软件进行疗效分析。结果rs1800947G单核苷酸多态性男性患者失眠评分较低，rs2794521CC男性患者焦虑/躯体症状评分较低，HAMD17总分较低。携带rs2794521TT的女性患者失眠评分较高，抗抑郁药疗效较差。结论CRPSNPs、rs1800947和rs2794521可能与抑郁症患者的抑郁症状存在性别相关。此外，rs2794521可能是女性患者抗抑郁药物疗效的预测指标。
Objective Although the pathogenesis of depression remains unclear, C-reactive protein (CRP) levels are commonly elevated in depressed patients. Thus, CRP single-nucleotide polymorphisms (SNPs) that influence CRP levels may be associated with depression. In the present study, we explored whether CRP SNPs are related to depressive symptoms and antidepressants efficacy in Han Chinese patients. Methods We analyzed data from 440 patients with first-episode depression. We obtained genome CRP SNPs, scores of the 17-item Hamilton Rating Scale for Depression 17 (HAMD17) and its four-factor at baseline and after 6 weeks. Quantitative trait analysis was performed using UNPHASED software and curative effects were analyzed using SPSS software. Results Male patients with SNP rs1800947G exhibited lower insomnia scores and rs2794521CC exhibited lower scores of anxiety/ physical symptoms, total HAMD17 score. Female patients with rs2794521TT exhibited higher scores of insomnia and lower antidepressants efficacy. Conclusion CRP SNPs rs1800947 and rs2794521 may be associated with depressive symptoms in patients with depression in a sex-specific fashion. Furthermore, rs2794521 may be a predictor of the efficacy of antidepressants in female patients.