Associations between Polymorphisms in the Solute Carrier Family 6 Member 3 and the Myelin Basic Protein Gene and Posttraumatic Stress Disorder.
Associations between Polymorphisms in the Solute Carrier Family 6 Member 3 and the Myelin Basic Protein Gene and Posttraumatic Stress Disorder.
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DOI：
10.24869/psyd.2019.235
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发表时间：
2019-06
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通讯作者：
Mirnesa Muminović Umihanić;R. Babić;N. Kravić;E. Avdibegović;A. Džubur Kulenović;F. Agani;M. Jakovljevič;D. Babic;A. Kučukalić;S. Kučukalić;Emina Šabić Džananović;A. Bravo Mehmedbašić;Aferdita Goci Uka;S. Haxhibeqiri;B. Hoxha;V. Haxhibeqiri;B. Aukst Margetić;N. Jakšić;Ana Čima Franc;D. Rudan;M. Pavlović;Elma Ferić Bojić;D. Marjanovic;N. Božina;C. Ziegler;C. Wolf;B. Warrings;K. Domschke;J. Deckert;O. Sinanović
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作者：
Mirnesa Muminović Umihanić;R. Babić;N. Kravić;E. Avdibegović;A. Džubur Kulenović;F. Agani;M. Jakovljevič;D. Babic;A. Kučukalić;S. Kučukalić;Emina Šabić Džananović;A. Bravo Mehmedbašić;Aferdita Goci Uka;S. Haxhibeqiri;B. Hoxha;V. Haxhibeqiri;B. Aukst Margetić;N. Jakšić;Ana Čima Franc;D. Rudan;M. Pavlović;Elma Ferić Bojić;D. Marjanovic;N. Božina;C. Ziegler;C. Wolf;B. Warrings;K. Domschke;J. Deckert;O. Sinanović
背景以往的研究表明，关于溶质载体家族6成员3(SLC6A3)基因多态性与创伤后应激障碍(PTSD)的多巴胺症状之间可能存在关联的研究结果不一致。一些研究还表明，髓鞘碱性蛋白(MBP)基因在几种精神疾病的病因学中具有重要作用。本研究旨在探讨SLC6A3和MBP基因多态性与创伤后应激障碍的关系，以及SLC6A3和MBP基因是否与创伤后应激障碍症状严重程度有关。研究对象和方法这项研究包括719名在东南欧经历过战争创伤的人(见)。对696名受试者进行了SLC6A3基因可变数目串联重复序列(VNTR)多态性的基因分型，并对703名受试者进行了MBP基因区域单核苷酸多态(SNP)rs12458282的基因分型。采用迷你国际神经精神病学访谈、临床管理创伤后应激障碍量表(CAPS)和简明症状自评量表(BSI)进行数据收集。结果创伤后应激障碍患者与非创伤后应激障碍患者SLC6A3和MBP基因多态性差异无统计学意义。此外，我们没有检测到这些不同的SLC6A3和MBP等位基因对创伤后应激障碍症状(CAPS)或BSI评分的显著影响。然而，终生PTSD患者中MBP rs12458282的结果可能表明主要等位基因(T)与CAPS评分升高有关。结论我们的研究结果不支持SLC6A3和MBP基因分析与战争创伤个体创伤后应激障碍的关联。我们发现，在终生PTSD患者中，MBP基因中的T等位基因rs12458282可能与较高的CAPS评分相关，这需要在提供更多统计能力的样本中进行测试。
BACKGROUND Previous research showed inconsistent results concerning a possible association between solute carrier family 6 member 3 (SLC6A3) gene polymorphisms and dopamine symptoms of posttraumatic stress disorder (PTSD). Several studies also indicate that the myelin basic protein (MBP) gene is of importance in the etiology of several psychiatric disorders. The aim of this study was to investigate the relation of distinct SLC6A3 and MBP gene polymorphisms with PTSD and whether SLC6A3 and MBP genotypes contribute to PTSD symptom severity. SUBJECTS AND METHODS The study included 719 individuals who had experienced war trauma in the South Eastern Europe (SEE). Genotypes of variable number tandem repeat (VNTR) polymorphism within the SLC6A3 gene were assessed in 696 participants, and the single nucleotide polymorphism (SNP) rs12458282 located within the MBP gene region was genotyped in a total of 703 subjects. The Mini International Neuropsychiatric Interview, the Clinical Administrated PTSD Scale (CAPS) and Brief Symptom Inventory (BSI), were used for data collection. RESULTS No significant differences concerning the investigated SLC6A3 and MBP polymorphisms was identifiable between PTSD and non PTSD participants. Also we could not detect significant influence of these distinct SLC6A3 and MBP alleles on the severity of PTSD symptoms (CAPS) or BSI scores. However, the results of MBP rs12458282 within the patients with lifetime PTSD may point to a possible correlation of the major allele (T) with elevated CAPS scores. CONCLUSIONS Our results do not support an association of the analysed SLC6A3 and MBP gene polymorphisms with PTSD in war traumatized individuals. We found that there is a possibility for a correlation of the T allele rs12458282 within the MBP gene with higher CAPS scores in lifetime PTSD patients which would need to be tested in a sample providing more statistical power.