Origins and evolution of the Europeans' genome: evidence from multiple microsatellite loci
Origins and evolution of the Europeans' genome: evidence from multiple microsatellite loci
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DOI：
10.1098/rspb.2006.3494
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发表时间：
2006-07-07
影响因子：
4.7
通讯作者：
Barbujani, Guido
中科院分区：
文献类型：
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作者：
Belle, Elise M. S.;Landry, Pierre-Alexandre;Barbujani, Guido
人们普遍认为，当前的欧洲基因库主要来源于旧石器时代的狩猎采集者和新石器时代的农耕祖先，但不同的研究对于这些贡献的相对比重存在分歧。我们利用五种不同的数值方法，根据235个个体的377个常染色体微卫星位点的数据，估算了欧洲人群的混合率。平均而言，近东（大概是新石器时代）的贡献在46%到66%之间，并且所有方法得出的混合估算结果都与距近东的距离呈强烈且显著的负相关。如果该模型的假设大致正确，即如果巴斯克人和近东人的基因组分别能很好地近似代表欧洲的旧石器时代和新石器时代的定居者，那么这些结果意味着欧洲人一半或更多的基因来自于一万年前迁徙到欧洲的近东祖先。如果这些假设不正确，我们的结果无论如何都表明渐变变异是欧洲人基因组的规律，而且从单一标记分析中得出的较低的近东混合估算值并不能反映在基因组层面观察到的模式。
There is general agreement that the current European gene pool is mainly derived from Palaeolithic hunting-gathering and Neolithic farming ancestors, but different studies disagree on the relative weight of these contributions. We estimated admixture rates in European populations from data on 377 autosomal microsatellite loci in 235 individuals, using five different numerical methods. On average, the Near Eastern (and presumably Neolithic) contribution was between 46 and 66%, and admixture estimates showed, with all methods, a strong and significant negative correlation with distance from the Near East. If the assumptions of the model are approximately correct, i.e. if the Basques' and Near Easterners' genomes represent a good approximation to the Palaeolithic and Neolithic settlers of Europe, respectively, these results imply that half or more of the Europeans' genes are descended from Near Eastern ancestors who immigrated in Europe 10 000 years ago. If these assumptions are incorrect, our results show anyway that clinal variation is the rule in the Europeans' genomes and that lower estimates of Near Eastern admixture obtained from the analysis of single markers do not reflect the patterns observed at the genomic level.