Interaction between Exercise, Dietary Restriction and Age-Related Bone Loss in a Rodent Model of Male Senile Osteoporosis
Interaction between Exercise, Dietary Restriction and Age-Related Bone Loss in a Rodent Model of Male Senile Osteoporosis
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DOI：
10.1159/000329113
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发表时间：
2012-01-01
期刊：
影响因子：
3.5
通讯作者：
Erben, Reinhold G.
中科院分区：
文献类型：
--
作者：
Bodnar, Marko;Skalicky, Monika;Erben, Reinhold G.
背景：老年性骨质流失的病理生理学以及是否可以通过运动预防老年性骨质流失仍然是一个有争议的问题。目的：探讨运动和轻度食物限制对老龄雄性大鼠尾骨骨密度和骨几何形状的长期影响。方法：以5 ~ 23月龄雄性Sprague-Dawley大鼠为研究对象。将大鼠分为4组：基线组、自由获取食物和跑步轮（RW）组、与RW组（PW）配对喂食组和自由获取食物的久坐对照组（SED）。所有的老鼠都被单独饲养。通过外周定量计算机断层扫描（pQCT）评估股骨和胫骨的体积骨密度和几何形状。此外，采用皮质骨组织形态学分析胫骨轴。结果：实验结束时，RW和PW大鼠体重相近。SED大鼠的体重比RW大鼠大31%。股骨和胫骨的pQCT分析以及胫骨轴的组织形态计量学分析显示，与RW和SED组相比，饮食限制导致骨髓腔增大，股骨和胫骨轴皮质变薄。与31%的重度SED大鼠相比，自愿跑步运动没有提供额外的保护，防止与年龄相关的骨质流失。在19至23个月大的SED动物中，运动或体重增加都不能完全预防与年龄相关的骨质流失。结论：饮食限制对骨密度和骨几何形状有明显的负面影响，跑步轮运动提供了部分保护，但不能预防与年龄相关的骨质流失。巴塞尔S. Karger股份有限公司版权所有
Background:The pathophysiology of age-related bone loss and whether age-related bone loss can be prevented by exercise are still a matter of debate. Objective: It was the aim of this study to investigate the long-term effects of exercise and mild food restriction on bone mineral density (BMD) and bone geometry in the appendicular skeleton of aging male rats. Methods: Male Sprague-Dawley rats were studied from 5 to 23 months of age. The rats were divided into 4 groups: baseline, free access to food and running wheels (RW), fed to pair weight with the RW group (PW) and sedentary control animals with free access to food (SED). All rats were housed individually. Volumetric BMD and geometry of femurs and tibiae were assessed by peripheral quantitative computed tomography (pQCT). In addition, the tibial shafts were analyzed by cortical bone histomorphometry. Results: At the end of the experiment, RW and PW rats had similar body weight. The body weight of SED rats was 31% greater than that of RW rats. pQCT analysis of femurs and tibiae as well as histomorphometric analysis of the tibial shafts showed that dietary restriction resulted in an enlargement of the marrow cavity and cortical thinning at the femoral and tibial shafts relative to the RW and SED groups. Voluntary running exercise provided no additional protection against age-related bone loss when compared with the 31% heavier SED control rats. Neither exercise nor increased body weight in SED animals could completely prevent age-related bone loss between 19 and 23 months of age. Conclusion: We conclude that dietary restriction had clear negative effects on BMD and bone geometry and that running wheel exercise provided partial protection but could not prevent age-related bone loss. Copyright (C) 2011 S. Karger AG, Basel