Gut microbiota shape B cell in health and disease settings
Gut microbiota shape B cell in health and disease settings
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DOI：
10.1002/jlb.1mr0321-660r
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发表时间：
2021-05
影响因子：
5.5
通讯作者：
Baichao Yu;Luman Wang;Y. Chu
中科院分区：
文献类型：
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作者：
Baichao Yu;Luman Wang;Y. Chu
最近越来越多的证据支持这样一种假设，即肠道微生物群和免疫系统之间复杂的相互作用深刻地影响着人类和小鼠的健康和疾病。在这种情况下，微生物群在培养和塑造宿主免疫系统方面发挥着重要作用，而宿主免疫系统反过来又调节肠道微生物群的多样性和功能以维持体内平衡。研究表明，肠道微生物群参与健康和疾病环境中B细胞的形成。在此，我们回顾了最近在了解微生物群如何调节B‐细胞发育方面的进展，重点是GALT中早期B‐细胞库的生成以及微生物产物，包括微生物抗原和代谢产物，如何影响B‐细胞活化和分化，最终调节B‐细胞功能。我们还讨论了致病条件下肠道微生物群和B细胞之间的相互作用，并强调了可用于治疗各种疾病的新方法。
Recent accumulating evidence supports the hypothesis that the intricate interaction between gut microbiota and the immune system profoundly affects health and disease in humans and mice. In this context, microbiota plays an important role in educating and shaping the host immune system which, in turn, regulates gut microbiota diversity and function to maintain homeostasis. Studies have demonstrated that intestinal microbiota participates in shaping B cells in health and disease settings. Herein, we review the recent progress in understanding how microbiota regulates B‐cell development, focusing on early‐life B‐cell repertoire generation in GALT and how microbial products, including microbial antigens and metabolites, affect B‐cell activation and differentiation to ultimately regulate B‐cell function. We also discuss the interaction between gut microbiota and B cells under pathogenic conditions and highlight new approaches that can be applied to treat various diseases.