Single-sided NMR for the diagnosis of osteoporosis: Diffusion weighted pulse sequences for the estimation of trabecular bone volume fraction in the presence of muscle tissue
Single-sided NMR for the diagnosis of osteoporosis: Diffusion weighted pulse sequences for the estimation of trabecular bone volume fraction in the presence of muscle tissue
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DOI：
10.1016/j.micromeso.2017.05.023
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发表时间：
2018-10-01
影响因子：
5.2
通讯作者：
Galvosas, P.
中科院分区：
文献类型：
--
作者：
Barbieri, M.;Brizi, L.;Galvosas, P.
骨体积分数（bone - volume - to - total - volume ratio, BV/TV）是评估骨微观结构的重要参数，与骨质疏松症骨折风险有关。虽然磁共振成像（MRI）可以评估体内骨微结构参数，但高场全身MRI扫描仪几乎不适合大规模筛查活动。近年来，提出了一种利用低场单面核磁共振在实验室中评估骨小梁（TB） BV/TV的新方法。本文提出了一种改进的技术，可以只检测来自骨髓的信号，而来自其他组织的结核病抑制信号可能存在于真实场景中的单面扫描仪的敏感体积中。改进是通过分子扩散滤波信号采集来实现的。基于特别设计的弥散加权T-1 - T-2脉冲序列的实验表明，使用弥散加权可以抑制肌肉和软骨信号。在这些实验的基础上，建立了一维测量方法，以便在核磁共振扫描仪的敏感体积中也存在肌肉组织的情况下，正确估计结核样品的BV/TV。采用核磁共振- mouse PM10和核磁共振- mole进行的实验，利用扩散加权脉冲序列，可能为使用单面扫描仪进行体内BV/TV评估铺平道路。(C) 2017爱思唯尔公司版权所有。
The bone volume fraction, defined as the Bone-Volume-To-Total-Volume ratio (BV/TV), is an important parameter in the assessment of the bone's micro-structure, and is related to the fracture risk in osteoporosis. Although Magnetic Resonance Imaging (MRI) can assess bone micro-architecture parameters in-vivo, high-field whole body MRI scanners are hardly suitable for wide-scale screening campaigns. Recently, a new NMR application to assess in laboratory the BV/TV of trabecular bone (TB) has been proposed using low-field single-sided NMR. This paper presents an improvement of this technique that allows detection of only the signal from the marrow in the TB suppressing signals from other tissues, which may be present in the sensitive volume of single-sided scanners in a real scenario. The improvement was achieved by filtering signal acquisition by molecular diffusion. Experiments based on an ad-hoc designed Diffusion Weighted T-1 - T-2 pulse sequence have demonstrated that muscle and cartilage signals can be suppressed by using diffusion weighting. On the basis of those experiments, a 1D measurement was established to allow correct estimation of the BV/TV of a TB sample also in the presence of muscle tissue in the sensitive volume of the NMR-scanner. The experiments presented, carried out with the NMR-MOUSE PM10 and the NMR-MOLE, exploiting diffusion-weighted pulse sequences, may pave the way for the in-vivo BV/TV evaluation using single-sided scanners. (C) 2017 Elsevier Inc. All rights reserved.