Age-related findings on MRI in neurofibromatosis type 1
Age-related findings on MRI in neurofibromatosis type 1
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DOI：
10.1007/s00247-006-0267-2
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发表时间：
2006-10-01
影响因子：
2.3
通讯作者：
North, Kathryn N.
中科院分区：
文献类型：
--
作者：
Gill, Deepak S.;Hyman, Shelley L.;North, Kathryn N.
背景：MRI上T2高信号（T2 H）是1型神经纤维瘤病（NF 1）患者最常见的CNS病变。目的：研究不同年龄组T2 H的频率、信号特征和定位。此外，我们研究了不同的MR成像序列在检测这些病变的敏感性。材料与方法：我们采用T2容积（T2-V）和常规MRI序列前瞻性研究了一组患有NF 1的儿童、青少年和年轻成人。病变被指定为离散或弥漫，并记录信号异常的区域。共研究了103例患者（年龄范围8.0-25.4岁，平均13.9岁）。结果：基底节（BG）和小脑/脑干（CB/BS）中T2 H的频率、大小和强度随年龄增长而降低。大多数丘脑和CB/BS病变是弥漫性的。在全部队列中，80%的患者有弥漫性双侧海马高信号，18.4%的患者有FLAIR最佳显示的半球病变;半球病变的频率或信号强度随年龄变化无显著差异。结论：通过MR成像的大脑半球和海马中的病变的患病率不随时间变化，这表明与BG和CB/BS中的病变不同的病理基础随着年龄的增长而消退。FLAIR和T2-V序列比标准T2加权序列更敏感。
Background: T2 hyperintensities (T2H) on MRI are the most common CNS lesions in individuals with neurofibromatosis type 1 (NF1). Objectives: The aim was to determine the frequency, signal characteristics and localization of T2H at different ages. In addition, we examined the sensitivity of different MR imaging sequences in detecting these lesions. Materials and methods: We studied prospectively a cohort of children, adolescents and young adults with NF1 using T2-volume (T2-V) and conventional MRI sequences. Lesions were designated as either discrete or diffuse, and the region of signal abnormality was recorded. A total of 103 patients were studied (age range 8.0-25.4 years, mean 13.9 years). Results: The frequency, size, and intensity of T2H decreased with age in the basal ganglia (BG) and the cerebellum/brainstem (CB/BS). The majority of thalamic and CB/BS lesions were diffuse. Of the total cohort, 80% had diffuse bilateral hippocampal hyperintensities and 18.4% had hemispheric lesions best demonstrated on FLAIR; there was no significant difference in the frequency or signal intensity of hemispheric lesions with age. Conclusion: Lesions in the cerebral hemispheres and hippocampus imaged by MR do not change in prevalence over time, suggesting a different pathological basis from the lesions in the in BG and CB/BS that resolve with age. FLAIR and T2-V sequences are more sensitive in detecting lesions than standard T2-weighted sequences.