Six‐Month Follow‐Up of Short‐Term Pharmacotherapy for Cocaine Dependence
Six‐Month Follow‐Up of Short‐Term Pharmacotherapy for Cocaine Dependence
复制标题
可卡因依赖短期药物治疗的六个月随访
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
H. Kleber
中科院分区：
文献类型：
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作者：
T. Kosten;F. Gawin;T. Kosten;C. Morgan;B. Rounsaville;R. Schottenfeld;H. Kleber
这项为期6个月的随访研究对72名患者中的43名进行了为期1116周的可卡因依赖药物治疗的随机临床试验，发现在6个月内，接受地昔帕明治疗的患者（44%）自我报告的可卡因戒断率显著高于接受锂（19%）或安慰剂（27%）治疗的患者。安慰剂组有更多的抑郁症（36%对6%）和每日酗酒（36%）。15%）。在临床试验期间戒断可卡因使用的能力是随访期间持续戒断的最强预测因素，这表明53%的人在6个月后仍然戒断。
This 6-month follow-up study of 43 of 72 patients who entered a 1116-week randomized clinical trial of pharmacotherapy for cocaine dependence found that self-reported cocaine abstinence during the 6 months was significantly greater in patients treated with desipramine (44%) than in those treated with lithium (19%) or placebo (27%). The placebo group had more occurrences of depression (36% vs. 6%) and daily alcohol abuse (36% us. 15%) than the medicated groups. The ability to abstain from cocaine use during the clinical trial was the strongest predictor of continued abstinence during the follow-up, which showed that 53% remained abstinent after 6 months.
适用于流动可卡因滥用者的人际心理治疗。
DOI：
10.3109/00952998509016860
发表时间：
1985
期刊：
The American journal of drug and alcohol abuse
影响因子：
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作者：
Rounsaville,BJ;Gawin,F;Kleber,H
通讯作者：
Kleber,H
地昔帕明促进最初的可卡因戒断。
影响因子：
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作者：
Gawin,FH;Kleber,HD;Byck,R;Rounsaville,BJ;Kosten,TR;Jatlow,PI;Morgan,C
通讯作者：
Morgan,C