Regenerated Luminal Epithelial Cells Are Derived from Preexisting Luminal Epithelial Cells in Adult Mouse Prostate
Regenerated Luminal Epithelial Cells Are Derived from Preexisting Luminal Epithelial Cells in Adult Mouse Prostate
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DOI：
10.1210/me.2011-1081
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发表时间：
2011-11-01
影响因子：
--
通讯作者：
Wang, Zhou
中科院分区：
文献类型：
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作者：
Liu, June;Pascal, Laura E.;Wang, Zhou
确定在雄激素剥夺和替代期间成人前列腺中再生的管腔上皮细胞的来源将提供对前列腺癌细胞的起源及其在雄激素剥夺治疗期间的命运的见解。上皮层中的前列腺干细胞被认为产生腔上皮。然而，干细胞参与前列腺再生的程度尚不清楚。在这份报告中，使用前列腺特异性抗原CreER（T2）为基础的遗传谱系标记/跟踪小鼠，预先存在的管腔上皮细胞被证明是一个来源的再生管腔上皮细胞在成年前列腺。前列腺腔上皮细胞可以在雄激素剥夺后存活，并能够在雄激素替代后增殖。前列腺癌细胞，通常表现出管腔上皮表型，可能保留这种内在的能力，以生存和再生的雄激素信号的变化作出反应，雄激素剥夺治疗前列腺癌的最终失败的机制提供了一部分。（分子内分泌学25：1849 - 1857，2011）
Determining the source of regenerated luminal epithelial cells in the adult prostate during androgen deprivation and replacement will provide insights into the origin of prostate cancer cells and their fate during androgen deprivation therapy. Prostate stem cells in the epithelial layer have been suggested to give rise to luminal epithelium. However, the extent of stem cell participation to prostate regrowth is not clear. In this report, using prostate-specific antigen-CreER(T2)-based genetic lineage marking/tracing in mice, preexisting luminal epithelial cells were shown to be a source of regenerated luminal epithelial cells in the adult prostate. Prostatic luminal epithelial cells could survive androgen deprivation and were capable of proliferating upon androgen replacement. Prostate cancer cells, typically exhibiting a luminal epithelial phenotype, may retain this intrinsic capability to survive and regenerate in response to changes in androgen signaling, providing part of the mechanism for the ultimate failure of androgen deprivation therapy in prostate cancer. (Molecular Endocrinology 25: 1849-1857, 2011)