Effect of Continuous Positive Airway Pressure on the Incidence of Hypertension and Cardiovascular Events in Nonsleepy Patients With Obstructive Sleep Apnea A Randomized Controlled Trial
Effect of Continuous Positive Airway Pressure on the Incidence of Hypertension and Cardiovascular Events in Nonsleepy Patients With Obstructive Sleep Apnea A Randomized Controlled Trial
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DOI：
10.1001/jama.2012.4366
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发表时间：
2012-05-23
影响因子：
120.7
通讯作者：
Montserrat, Josep M.
中科院分区：
文献类型：
--
作者：
Barbe, Ferran;Duran-Cantolla, Joaquin;Montserrat, Josep M.
持续气道正压通气（CPAP）是阻塞性睡眠呼吸暂停（OSA）患者的一线治疗方法。然而，它的适应症为所有患者的睡眠呼吸障碍，无论白天的症状，是unclear.Objective评估CPAP治疗的影响，对高血压或心血管事件的发病率在一个队列的nonsleeping患者与OSA.Design，设置，和患者多中心，平行组，随机对照试验在14所教学医院在西班牙。在2004年5月至2006年5月期间，725名连续患者入组，他们的呼吸暂停-低通气指数为20小时（-1）或更高，埃普沃思嗜睡量表评分为10或更低（评分范围为0-24，
Context Continuous positive airway pressure (CPAP) is the first-line treatment for patients with symptomatic obstructive sleep apnea (OSA). However, its indication for all patients with sleep-disordered breathing, regardless of daytime symptoms, is unclear.Objective To evaluate the effect of CPAP treatment on the incidence of hypertension or cardiovascular events in a cohort of nonsleepy patients with OSA.Design, Setting, and Patients Multicenter, parallel-group, randomized controlled trial in 14 teaching hospitals in Spain. Between May 2004 and May 2006, 725 consecutive patients were enrolled who had an apnea-hypopnea index of 20 h(-1) or greater and an Epworth Sleepiness Scale score of 10 or less (scores range from 0-24, with values