Sex Hormone-Binding Globulin in Children and Adolescents.
Sex Hormone-Binding Globulin in Children and Adolescents.
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DOI：
10.4274/jcrpe.2764
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发表时间：
2016-03-05
影响因子：
1.9
通讯作者：
Winters SJ
中科院分区：
文献类型：
--
作者：
Aydın B;Winters SJ
性激素结合球蛋白 (SHBG) 是一种循环糖蛋白，可在血液中运输睾酮和其他类固醇。近年来，人们对性激素结合球蛋白 (SHBG) 的兴趣日益浓厚，因为它与肥胖和胰岛素抵抗呈负相关，而且许多研究已将性激素结合球蛋白 (SHBG) 循环水平较低与代谢综合征、2 型糖尿病、非酒精性脂肪肝、多囊卵巢综合征和青春期早期联系起来。本综述的目的是总结分子、临床、内分泌和流行病学研究结果，以说明血浆性激素结合球蛋白 (SHBG) 的测量如何在儿童临床医学中发挥作用。
Sex hormone-binding globulin (SHBG) is a circulating glycoprotein that transports testosterone and other steroids in the blood. Interest in SHBG has escalated in recent years because of its inverse association with obesity and insulin resistance, and because many studies have linked lower circulating levels of SHBG to metabolic syndrome, type 2 diabetes, nonalcoholic fatty liver disease, polycystic ovary syndrome, and early puberty. The purpose of this review is to summarize molecular, clinical, endocrine, and epidemiological findings to illustrate how measurement of plasma SHBG may be useful in clinical medicine in children.