Strategies to develop methods using ion-molecule reactions in a quadrupole reaction cell to overcome spectral overlaps in inductively coupled plasma mass spectrometry
Strategies to develop methods using ion-molecule reactions in a quadrupole reaction cell to overcome spectral overlaps in inductively coupled plasma mass spectrometry
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DOI：
10.1039/b511464k
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发表时间：
2006-02-01
影响因子：
3.4
通讯作者：
Jones, DR
中科院分区：
文献类型：
--
作者：
Olesik, JW;Jones, DR
使用离子-分子反应克服光谱重叠的ICP-MS仪器正变得越来越普遍。系统地描述了在四极反应池中使用离子-分子反应的方法的发展策略。离子-分子反应可用于去除光谱重叠离子，使得分析物元素离子可在几乎没有背景的情况下测量。或者，离子-分子反应可用于在背景较低的情况下以较高质量产生新的含分析物的产物离子。讨论了每种方法的考虑因素，包括反应气体的选择、反应池带通的调整和气体流速的优化。实例给出了可用的动力学速率常数，热力学数据和实验ICP-MS测量，以说明每个考虑在开发中使用离子分子反应的方法。为了防止产生不需要的反应产物离子，从电池中排出反应物离子是定量评估的。
ICP-MS instruments that use ion-molecule reactions to overcome spectral overlaps are becoming more widely available. Strategies to develop methods that use ion-molecule reactions in a quadrupole reaction cell are systematically described. Ion-molecule reactions may be used to remove the spectral overlap ion so that the analyte elemental ion can be measured with little background. Alternatively, ion-molecule reactions can be used to produce a new analyte-containing product ion at a higher mass where the background is low. Considerations for each approach including selection of the reaction gas, adjustment of the reaction cell bandpass and optimization of the gas flow rate are discussed. Examples are given with available kinetic rate constants, thermodynamic data and experimental ICP-MS measurements to illustrate each consideration in development of methods using ion-molecule reactions. Rejection of reactant ions from the cell in order to prevent generation Of undesired reaction product ions is quantitatively assessed.