Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis.

Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis.
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DOI:
10.1038/nrm3175
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发表时间:
2011-08-23
期刊:
Nature reviews. Molecular cell biology
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为了提供稳定的环境屏障,表皮需要一个由细胞骨架元素和细胞连接组成的完整网络。尽管如此,表皮是人体最具活力的组织之一,它会不断地自我再生,并对皮肤的侮辱做出反应。当角质形成细胞从基底室向角化层移动时,它们会完全重组其黏附连接和细胞骨架。这些建筑构件不仅仅是铆钉和支架--它们是调节表皮极化、信号和屏障形成的表皮形态发生的积极参与者。
To provide a stable environmental barrier, the epidermis requires an integrated network of cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the body’s most dynamic tissues, continually regenerating itself and responding to cutaneous insults. As keratinocytes journey from the basal compartment towards the cornified layers, they completely reorganize their adhesive junctions and cytoskeleton. These architectural components are more than just rivets and scaffolds — they are active participants in epidermal morphogenesis that regulate epidermal polarization, signalling and barrier formation.
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