[Effects of lansoprazole on indomethacin-induced gastric bleeding and mucosal lesions in rats].
[Effects of lansoprazole on indomethacin-induced gastric bleeding and mucosal lesions in rats].
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兰索拉唑对吲哚美辛所致大鼠胃出血及黏膜病变的影响
DOI：
10.1254/fpj.108.6_323
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
N. Inatomi
中科院分区：
文献类型：
--
作者：
I. Murakami;S. Asano;K. Yukishige;H. Nagaya;H. Satoh;N. Inatomi
观察兰索拉唑与奥美拉唑、法莫替丁、雷尼替丁对吲哚美辛致大鼠胃出血及粘膜损伤的影响。兰索拉唑对吲哚美辛致胃出血有抑制作用，其ID50值为0.29 mg/kg。奥美拉唑和法莫替丁显著抑制胃出血，但雷尼替丁的抑制作用微不足道。发现兰索拉唑对胃出血的抑制作用与胃酸分泌之间存在相关性，在胃灌注液中加入50 mM-HCl后，其对胃出血的抑制作用几乎完全消失，说明兰索拉唑对胃出血的抑制作用主要是由于其抗分泌作用。兰索拉唑对吲哚美辛诱导的胃损害的ID50值为0.10 mg/kg，而组胺h2受体拮抗剂对吲哚美辛诱导的胃损害没有明显的抑制作用。奥美拉唑、法莫替丁和雷尼替丁的ID50值分别为0.69、2.58和24.6 mg/kg。说明兰索拉唑对吲哚美辛引起的胃出血和黏膜病变有较强的抑制作用，可用于急性胃黏膜病变的治疗。
The effects of lansoprazole given intravenously on indomethacin-induced gastric bleeding and mucosal lesions were investigated in rats in comparison with those of omeprazole, famotidine and ranitidine. Lansoprazole inhibited gastric bleeding induced by indomethacin with an ID50 value of 0.29 mg/kg. Omeprazole and famotidine significantly inhibited gastric bleeding, but ranitidine provided negligible inhibition. A correlation was found between the inhibitory action of lansoprazole on gastric bleeding, and acid secretion, and its inhibitory action on gastric bleeding was almost completely abolished by adding 50 mM-HCl to the gastric perfusate, suggesting that lansoprazole's inhibitory action on gastric bleeding was mainly due to its antisecretory action. Lansoprazole inhibited the development of gastric lesions induced by indomethacin with an ID50 value of 0.10 mg/kg, whereas histamine H2-receptor antagonists did not display a potent inhibitory effect. ID50 values for omeprazole, famotidine and ranitidine were 0.69, 2.58 and 24.6 mg/kg, respectively. These results indicate that lansoprazole has a potent inhibitory action on indomethacin-induced gastric bleeding and mucosal lesions and that it is useful in the treatment of acute gastric mucosal lesions.