CD1-RESTRICTED T-CELL RECOGNITION OF MICROBIAL LIPOGLYCAN ANTIGENS
CD1-RESTRICTED T-CELL RECOGNITION OF MICROBIAL LIPOGLYCAN ANTIGENS
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DOI：
10.1126/science.7542404
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发表时间：
1995-07-14
期刊：
影响因子：
56.9
通讯作者：
MODLIN, RL
中科院分区：
文献类型：
--
作者：
SIELING, PA;CHATTERJEE, D;MODLIN, RL
长期以来，T细胞识别由主要组织相容性复合体（MHC）分子呈递的肽抗原一直是范例。然而，非肽抗原可以通过人CD 1b分子呈递给T细胞，这些分子不是由MHC编码的。与致病性相关的主要一类微生物抗原是脂聚糖。这里显示，人CD 1b将定义的分枝杆菌脂聚糖脂阿拉伯甘露聚糖（LAM）呈递给携带α β T细胞受体的淋巴细胞。这些脂多糖抗原的呈递需要内化和内体酸化。T细胞识别需要具有α（1->2）键和磷脂酰肌醇单元的甘露糖苷。由LAM激活的T细胞产生干扰素γ并具有细胞溶解性。因此，一类重要的微生物分子，脂聚糖，是人类T细胞识别的外来抗原的一部分。
It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with alpha(1-->2) linkages and a phosphatidylinositol unit. T cells activated by LAM produced interferon gamma and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells.