Antigenic stability of H1N1 pandemic vaccines correlates with vaccine strain
Antigenic stability of H1N1 pandemic vaccines correlates with vaccine strain
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DOI：
10.1016/j.vaccine.2010.12.120
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发表时间：
2011-02-11
期刊：
影响因子：
5.5
通讯作者：
Li, Xuguang
中科院分区：
文献类型：
--
作者：
Farnsworth, Aaron;Cyr, Terry D.;Li, Xuguang
2009年，一种新型H1N1流感病毒出现并迅速传播。然而，在疫苗批次发布后不久，由于HA效价意外下降，保质期被下调。在本研究中，我们发现两种单价H1N1/2009疫苗制剂的稳定性和抗原含量存在差异。这些似乎是由于用于制备疫苗的A/California/7/2009型流感毒株的差异而引起的。英国皇家版权所有(C) 2010出版的爱思唯尔有限公司版权所有。
In 2009 a novel H1N1 influenza virus emerged and spread rapidly. Soon after vaccine lots were released, however, the shelf life was revised downward due to an unexpected decrease in HA potency. In this study, we found differences in both stability and antigenic content of two monovalent H1N1/2009 vaccine preparations. These appear to have arisen due to differences in the A/California/7/2009-like influenza strain used to prepare vaccine. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.