A Low-Power, “Architectural,” Clue to the Follicular Variant of Papillary Thyroid Adenocarcinoma in Aspiration Biopsy
A Low-Power, “Architectural,” Clue to the Follicular Variant of Papillary Thyroid Adenocarcinoma in Aspiration Biopsy
复制标题
抽吸活检中甲状腺乳头状腺癌滤泡变异的低倍“结构”线索
DOI：
10.1159/000326362
复制
发表时间：
2000
期刊：
影响因子：
1.8
通讯作者：
J. Waisman
中科院分区：
文献类型：
--
作者：
Zhanqing Yan;Grace C H Yang;J. Waisman
客观化
目的：在Diff-Quik染色的甲状腺活检涂片中寻找诊断滤泡型乳头状甲状腺腺癌(FVP)的低倍数或“构造性”线索，以帮助快速诊断FVP，特别是作为冰冻切片的补充。
研究设计
将23例经组织学证实的FVP与23例经乳头状腺癌(PTA)、23例经组织学证实的滤泡性肿瘤(FN)(即腺瘤或高分化腺癌)和23例胶样结节(CN)的涂片进行比较。研究并比较了四组的低功耗(10倍)特性。
结果
我们的研究表明，FvP呈单层细胞片状，轮廓不规则，分枝状，区别于FN内轮廓光滑的均匀微滤泡和CN内发现的大的、圆形或椭圆形的单层滤泡细胞。FVP具有经典PTA的所有特征，除了后者中发现的更大、更复杂的上皮细胞和砂样小体。
结论
甲状腺抽吸物DIFF快速染色涂片的低倍数检查中可见明显的上皮细胞分支片，这是快速诊断FVP的第一条现成线索。诊断可以通过随后对巴氏涂片和组织切片中的细胞核进行仔细的评估来确认。
OBJECTIVE
To search for low-power, or "architectural," clues to the diagnosis of the follicular variant of papillary thyroid adenocarcinoma (FVP) in Diff-Quik-stained aspiration biopsy smears in order to aid in the rapid diagnosis of FVP, especially as a complement to frozen sections.
STUDY DESIGN
The smears of 23 cases, each with tissue-proven FVP, were compared to those of 23 cases of classic papillary thyroid adenocarcinoma (PTA), 23 cases of tissue-proven follicular neoplasms (FN) (i.e., adenoma or well-differentiated adenocarcinoma) and 23 samples of colloid nodules (CN). The low-power (10x) features of the four groups were studied and compared.
RESULTS
Our study showed that FVP exhibited monolayered cellular sheets with branched, irregular contours, which can be distinguished from the uniform microfollicles with smooth contours formed in FN and the large, round or oval monolayered sheets of follicular cells found in CN. FVP shared all of the features of classic PTA except for the larger, complex sheets of epithelial cells and psammoma bodies found in the latter.
CONCLUSION
The branched sheets of epithelial cells evident during low-power examination of Diff-Quick-stained smears of thyroid aspirates are a ready first clue to the rapid diagnosis of FVP. The diagnosis can be confirmed by subsequent careful evaluation of nuclei in Papanicolaou-stained smears and sections of tissue.