METABOLIC EFFECTS OF ARGININE IN A HEALTHY ELDERLY POPULATION
METABOLIC EFFECTS OF ARGININE IN A HEALTHY ELDERLY POPULATION
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DOI：
10.1177/0148607195019003227
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发表时间：
1995-05-01
影响因子：
3.4
通讯作者：
BARBUL, A
中科院分区：
文献类型：
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作者：
HURSON, M;REGAN, MC;BARBUL, A
最近，人们对使用精氨酸来刺激免疫反应和促进伤口愈合有了很大的兴趣。在本研究中，研究了口服精氨酸对45名健康、不吸烟的老年志愿者代谢的影响。受试者被分为两组，接受精氨酸天冬氨酸（17g游离精氨酸）（n = 30）或安慰剂（n = 15）。这些补充剂持续服用14天。饮食中食物的摄入量不受控制。比较添加前后的血液化学、血脂、血清胰岛素样生长因子-1水平和氮平衡作为营养状况指标。与对照组（0.11 +/- 0.47 g N, p = 0.0114）相比，补充两周精氨酸可显著提高血清胰岛素样生长因子浓度，改善氮平衡（2.0 +/- 0.41 g N）。此外，精氨酸补充组表现出血清总胆固醇降低，低密度脂蛋白减少，但高密度脂蛋白部分没有减少，导致低密度脂蛋白与高密度脂蛋白比例增加。在这个剂量的精氨酸没有观察到不良反应。数据表明，口服精氨酸补充剂可以安全地用于老年人。
Recently there has been much interest in the use of arginine to stimulate immune responses and to promote wound healing. In the present study, the effect of an oral supplementation with arginine on the metabolism of 45 healthy, nonsmoking, elderly volunteers was investigated. Subjects were divided into two groups that received either arginine aspartate (17 g free arginine) (n = 30) or a placebo (n = 15). The supplements were taken for a period of 14 days. Dietary intake of food was not controlled. Blood chemistry, lipid profiles, and as an index of nutritional status, serum insulin-like growth factor-1 levels and nitrogen balance were compared before and after supplementation. Two weeks of arginine supplementation led to a significant elevation of serum insulin-like growth factor concentrations and an improved and positive nitrogen balance (2.0 +/- 0.41 g N) when compared with controls (0.11 +/- 0.47 g N; p = 0.0114). In addition the arginine-supplemented group demonstrated a decreased total serum cholesterol with a reduction in the low-density lipoprotein but not the high-density lipoprotein fraction resulting in a increase in the ratio of low- to high-density lipoprotein fraction. No adverse effects were observed at this dosage of arginine. The data suggest that oral arginine supplementation may be used safely in elderly humans.