Endogenous nitric oxide required for an integrative respiratory function in the cat brain.
Endogenous nitric oxide required for an integrative respiratory function in the cat brain.
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猫脑综合呼吸功能所需的内源性一氧化氮。
DOI：
10.1152/jn.1992.68.5.1910
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发表时间：
1992
影响因子：
2.5
通讯作者：
Speck,DF
中科院分区：
文献类型：
--
作者：
Ling,L;Karius,DR;Fiscus,RR;Speck,DF
1.在去大脑和去小脑猫的脑桥呼吸组（PRG）的不连续区域内微量注射一氧化氮（NO）相关药物，以观察NO在脑桥呼吸功能中的作用。2.微量注射N ω-硝基-L-精氨酸（L-NNA，NO合成酶抑制剂），但不是D-NNA（无活性的对映体），显着延长了所有10只猫的吸气时间时，肺膨胀被扣留。3.在三只猫的相同部位微量注射L-精氨酸（NO合成酶底物），L-NNA产生的吸气延长被部分逆转。4.我们的结论是，内源性生产NO从L-精氨酸在PRG区域参与正常功能的脑桥pneotaxic机制。这些研究结果提供了第一个决定性的证据，内源性NO的形成参与呼吸节律产生相关的机制。
1. The involvement of nitric oxide (NO) in the respiratory function of the pons was examined by microinjecting NO synthase-related drugs into discrete regions of the pontine respiratory group (PRG) in decerebrate and decerebellate cats. 2. Microinjection of N omega-nitro-L-arginine (L-NNA, inhibitor of NO synthase), but not D-NNA (the inactive enantiomer), significantly prolonged the duration of inspiration in all 10 cats when lung inflation was withheld. 3. The prolongation of inspiration produced by L-NNA was partially reversed in three cats by microinjections of L-arginine (NO synthase substrate) at the same sites. 4. We conclude that endogenous production of NO from L-arginine in the PRG region is involved in the normal function of the pontine pneumotaxic mechanism. These findings provide the first conclusive evidence that endogenous NO formation is involved in the mechanisms associated with respiratory rhythm generation.